Leukemia, lymphoma and multiple myeloma mortality (1950-1999) and incidence (1969-1999) in the Eldorado uranium workers cohort.
Leukemia, lymphoma and multiple myeloma mortality (1950-1999) and incidence (1969-1999) in the Eldorado uranium workers cohort.
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埃尔多拉多铀工人队列中的白血病、淋巴瘤和多发性骨髓瘤死亡率（1950-1999 年）和发病率（1969-1999 年）。
DOI：
10.1016/j.envres.2014.01.002
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发表时间：
2014
影响因子：
8.3
通讯作者：
Thompson,PatsyA
中科院分区：
文献类型：
--
作者：
Zablotska,LydiaB;Lane,RachelSD;Frost,StanleyE;Thompson,PatsyA
铀工人长期暴露于低水平的氡衰变产物 (RDP) 和伽马 (γ) 辐射。急性和高剂量 γ 辐射引起的白血病风险已得到充分表征，但较低剂量和剂量率以及 RDP 暴露带来的风险存在争议。很少有研究评估铀工人患其他血液癌症的风险。本研究的目的是分析 1932 年至 1980 年首次使用的埃尔多拉多铀矿矿工和加工者群体中与辐射相关的血液癌风险与累积 RDP 暴露和 γ 射线剂量的关系。平均累积RDP照射量为100.2工作水平月，平均累积全身γ辐射剂量为52.2毫西弗。我们在该队列中发现了 101 例死亡和 160 例血液癌症病例。总体而言，与加拿大一般男性人口相比，男性工人的所有结果的死亡率和癌症发病率都较低，这可能是健康工人的影响。 RDP 暴露或 γ 射线剂量或两者的组合与死亡率或任何血液癌症的发病率之间没有发现统计学上显着的关联。我们观察到，随着 γ 射线剂量的增加，慢性淋巴细胞白血病 (CLL) 和霍奇金淋巴瘤 (HL) 发病率以及非霍奇金淋巴瘤 (NHL) 死亡率出现一致但无统计学意义的显着增加。这些发现与最近关于 γ 辐射暴露后 CLL 和 NHL 发病风险增加的研究一致。需要进一步的研究来了解低剂量 γ 辐射导致其他血液癌症的风险。
Uranium workers are chronically exposed to low levels of radon decay products (RDP) and gamma (γ) radiation. Risks of leukemia from acute and high doses of γ-radiation are well-characterized, but risks from lower doses and dose-rates and from RDP exposures are controversial. Few studies have evaluated risks of other hematologic cancers in uranium workers. The purpose of this study was to analyze radiation-related risks of hematologic cancers in the cohort of Eldorado uranium miners and processors first employed in 1932–1980 in relation to cumulative RDP exposures and γ-ray doses. The average cumulative RDP exposure was 100.2 working level months and the average cumulative whole-body γ-radiation dose was 52.2 millisievert. We identified 101 deaths and 160 cases of hematologic cancers in the cohort. Overall, male workers had lower mortality and cancer incidence rates for all outcomes compared with the general Canadian male population, a likely healthy worker effect. No statistically significant association between RDP exposure or γ-ray doses, or a combination of both, and mortality or incidence of any hematologic cancer was found. We observed consistent but non-statistically significant increases in risks of chronic lymphocytic leukemia (CLL) and Hodgkin lymphoma (HL) incidence and non-Hodgkin lymphoma (NHL) mortality with increasing γ-ray doses. These findings are consistent with recent studies of increased risks of CLL and NHL incidence after γ-radiation exposure. Further research is necessary to understand risks of other hematologic cancers from low-dose exposures to γ-radiation.