Regulation mechanisms underlying the biosynthesis of daptomycin and related lipopeptides
Regulation mechanisms underlying the biosynthesis of daptomycin and related lipopeptides
复制标题
达托霉素及相关脂肽生物合成的调控机制
DOI：
10.1002/jcb.23414
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发表时间：
2012-03-01
影响因子：
4
通讯作者：
Xie, Jianping
中科院分区：
文献类型：
--
作者：
Liao, Guojian;Shi, Tinyu;Xie, Jianping
达托霉素是一种脂肽类抗生素，用于治疗革兰氏阳性病原体感染，包括耐药菌株。深入研究其生物合成和调控机制，对于这一日益重要的抗生素的代谢工程改良至关重要。近年来，达托霉素生物合成及其调控的分子机制研究取得了重大进展。在我们的综述中更新了这些信息，特别关注整合各种生理和环境输入的调控网络。这将为达托霉素生物合成的调控机制提供新的见解，并为菌株改良以提高达托霉素产量提供节点。J.细胞。113：735741，2012. (C)2011 Wiley Periodicals，Inc.
Daptomycin is a lipopeptide antibiotics used to treat Gram-positive pathogens infections, including drug-resistant strains. In-depth exploration of its biosynthesis and regulation is crucial for metabolic engineering improvement of this ever-increasing important antibiotic. The past years have witnessed the significant progresses in the understanding of the molecular mechanisms underlying the biosynthesis and regulation of daptomycin. This information was updated in our review, with special focus on the regulatory network integrating a wide variety of physiological and environmental inputs. This should provide novel insight into the regulatory mechanism of biosynthesis of daptomycin and nodes for strain improvement to increase the yields of daptomycin. J. Cell. Biochem. 113: 735741, 2012. (C) 2011 Wiley Periodicals, Inc.