Pancreatic cancer takes its Toll.
Pancreatic cancer takes its Toll.
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胰腺癌造成了损失。
DOI：
10.1084/jem.21212insight1
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发表时间：
2015-11-16
期刊：
影响因子：
--
通讯作者：
Sage J
中科院分区：
文献类型：
--
作者：
Mazur PK;Sage J
示意图描述了TLR9激活在PDAC的上皮、间质和炎性间隔中的具体作用。TLR9激活在胰腺肿瘤发生中的促进肿瘤作用的拟议模型确定PSCs是炎症过程的关键组成部分。TLR9激活的PSCs通过分泌CCL11介导其在上皮室的促肿瘤作用。此外，TLR9的激活可能通过促进MDSC的增殖和通过CCL3的分泌间接增加T细胞的数量而产生免疫抑制的微环境，这两者都是使PDAC中的细胞毒性T细胞(CTL)失效的关键。
Schematic depicts specific effects of TLR9 activation in epithelial, stromal, and inflammatory compartments in PDAC. A proposed model of tumor-promoting effects of TLR9 activation in pancreas tumorigenesis identifies PSCs as a key component of the inflammatory process. TLR9-activated PSCs mediate their protumorigenic effects on the epithelial compartment via CCL11 secretion. In addition, TLR9 activation may generate an immunosuppressive microenvironment by promoting MDSC proliferation and indirectly increasing T reg numbers via CCL3 secretion, both critical to disable cytotoxic T cells (CTL) in PDAC.