IRCINOL-A AND IRCINOL-B, FIRST ANTIPODES OF MANZAMINE-RELATED ALKALOIDS FROM AN OKINAWAN MARINE SPONGE
IRCINOL-A AND IRCINOL-B, FIRST ANTIPODES OF MANZAMINE-RELATED ALKALOIDS FROM AN OKINAWAN MARINE SPONGE
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DOI：
10.1016/s0040-4020(01)85280-7
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发表时间：
1994-07-04
期刊：
影响因子：
2.1
通讯作者：
KOBAYASHI, J
中科院分区：
文献类型：
--
作者：
TSUDA, M;KAWASAKI, N;KOBAYASHI, J
从冲绳海绵Amphimedon sp.中分离到两种新的manzamine相关生物碱，ircinols A(1)和B(2)，根据广泛的二维核磁共振数据和化学相关性，它们的结构分别为ircinols A和ircinols B在C-1上醇形式的对映体。化合物1和2是第一个具有与曼扎胺类生物碱相反绝对构型的例子。
Two new manzamine-related alkaloids, ircinols A (1) and B (2), have been isolated from the Okinawan marine sponge Amphimedon sp. and the structures elucidated to be enantiomers of alcoholic forms at C-1 of ircinals A and B, respectively, on the basis of extensive 2D NMR data and chemical correlations. Compounds 1 and 2 are the first examples possessing opposite absolute configurations to those of manzamine alkaloids.