Ccdc85C, a causative protein for hydrocephalus and subcortical heterotopia, is expressed in the systemic epithelia with proliferative activity in rats
Ccdc85C, a causative protein for hydrocephalus and subcortical heterotopia, is expressed in the systemic epithelia with proliferative activity in rats
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DOI：
10.14670/hh-11-589
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发表时间：
2015-07-01
影响因子：
2
通讯作者：
Kuwamura, Mitsuru
中科院分区：
文献类型：
--
作者：
Tanaka, Natsuki;Izawa, Takeshi;Kuwamura, Mitsuru
Ccdc 85 c基因是引起非梗阻性脑积水和皮质下异位的自发突变型小鼠的致病基因。Ccdc 85 C蛋白的详细功能尚未阐明。为了揭示Ccdc 85 C的作用，我们检测了Ccdc 85 C在大鼠全身发育器官中的分布和表达模式。Ccdc 85 C在各种单层上皮中表达，但在复层上皮中不表达。在各种上皮细胞中，Ccdc 85 C定位于细胞-细胞连接处，其表达在顶端连接处较强。在发育期表达较强，随发育进程逐渐减弱。Ccdc 85 C的分布与增殖期上皮细胞的分布一致。这些结果表明，Ccdc 85 C在单纯上皮细胞的增殖特性中起重要作用。
Coiled-coil domain containing 85c (Ccdc85c) is a causative gene for spontaneous mutant mouse with non-obstructive hydrocephalus and subcortical heterotopia. Detailed functions of Ccdc85C protein have not been clarified. To reveal roles of Ccdc85C, we examined the distribution and expression pattern of Ccdc85C in the systemic developing organs in rats. Ccdc85C was expressed in various simple epithelia but not stratified epithelia. In the various epithelia, Ccdc85C was localized at cell-cell junctions and its expression was strong at apical junctions. Furthermore, intense expression was seen at developing period and gradually decreased with advancing development. Distribution of Ccdc85C coincides with that of proliferating epithelial cells. These results suggest that Ccdc85C plays an important role in the proliferative property of simple epithelia.