A critical review on polymer-based bio-engineered materials for scaffold development
A critical review on polymer-based bio-engineered materials for scaffold development
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DOI：
10.1016/j.compositesb.2006.06.014
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发表时间：
2007-01-01
影响因子：
13.1
通讯作者：
Hui, David
中科院分区：
文献类型：
--
作者：
Cheung, Hoi-Yan;Lau, Kin-Tak;Hui, David
自上个十年以来，组织工程在为获取组织、植入物和假体的外科手术提供更可行的替代方案方面显示出了惊人的前景。由于生物材料技术的快速发展，现在医生可以使用患者的细胞来修复骨科缺损，如局部关节软骨病变。为了支持三维组织的形成，最近开发了由生物相容性和生物可吸收的聚合物和复合材料制成的支架，用于为受损的身体和细胞结构提供临时支撑。虽然陶瓷和金属材料已被广泛接受用于种植体的发展，但其不可吸收性和需要二次手术，这给患者带来了额外的负担，限制了它们的广泛应用。本文主要介绍软骨组织工程的概念、常用的生物工程材料和生物支架材料的发展趋势。(c)2006爱思唯尔有限公司保留所有权利。
dSince the last decade, tissue engineering has shown a sensational promise in providing more viable alternatives to surgical procedures for harvested tissues, implants and prostheses. Due to the fast development on biomaterial technologies, it is now possible for doctors to use patients' cells to repair orthopedic defects such as focal articular cartilage lesions. In order to support the three-dimensional tissue formation, scaffolds made by biocompatible and bioresorbable polymers and composite materials, for providing temporary support of damaged body and cell structures have been developed recently. Although ceramic and metallic materials have been widely accepted for the development of implants, its non-resorbability and necessity of second surgical operation, which induces extra for the patients, limit their wide applications. This review article aims at introducing (i) concept of cartilage tissue engineering, (ii) common types of bio-engineered materials and (iii) future development of biomaterial scaffolds. (c) 2006 Elsevier Ltd. All rights reserved.