Prostaglandin E2 accelerated recovery of chemotherapy-induced intestinal damage by increasing expression of cyclin D.
Prostaglandin E2 accelerated recovery of chemotherapy-induced intestinal damage by increasing expression of cyclin D.
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前列腺素 E2 通过增加细胞周期蛋白 D 的表达来加速化疗引起的肠道损伤的恢复。
DOI：
10.1016/j.yexcr.2020.111819
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发表时间：
2020-01
影响因子：
3.7
通讯作者：
Zeng Huihong
中科院分区：
文献类型：
--
作者：
Yue Mengzhen;Shao Lijian;Cheng Jiaoqi;Fan Ying;Cai Xueqin;Li Huan;Li Manjun;Zhang Xinxin;Fu Aixiang;Huang Yanqiu;Nie Chengtao;Long Fei;Chen Hongping;Zhu Qingxian;Zeng Huihong
肠干细胞在维持化疗和放疗后的肠道内环境稳定中起着至关重要的作用。已有文献证明前列腺素E2（PGE 2）治疗在体外和体内改善造血干细胞功能，但PGE 2与肠道干细胞之间的关系尚不清楚。目前，小鼠暴露于PGE 1、dmPGE 2和吲哚美辛。通过分析Olfm 4 +ISCs来评估ISCs的数量和功能。在5-氟尿嘧啶（5-FU）诱导的肠损伤小鼠模型上研究dmPGE 2的肠保护作用。结果显示，dmPGE 2处理，而不是PGE 1，以剂量和时间依赖性方式增加Olfm 4 +ISCs的数量。吲哚美辛处理减少Olfm 4 + ISC的数量。短期dmPGE 2治疗对肠道的有益作用在5 FU诱导的肠道损伤模型中得到支持。我们的数据显示，5 FU处理显著减少了肠中Olfm 4 +ISCs和杯状细胞的数量，这可以通过dmPGE 2处理来改善。dmPGE 2通过增加肠组织cyclin D1和D2的表达，促进5 FU诱导的ISC损伤的恢复。此外，dmPGE 2处理诱导的cyclin D1和D2的表达可能是通过上调肠道FOXM 1的表达来介导的。这些发现表明PGE 2是一种有效的保护剂，可以对抗化疗引起的肠道损伤。
Intestinal stem cells (ISCs) play a crucial role in maintaining intestinal homeostasis upon chemotherapy and radiotherapy. It has been documented that prostaglandin E2 (PGE2) treatment improved hematopoietic stem cell function in vitro and in vivo, while the relationship between PGE2 and intestinal stem cells remains unclear. Presently, mice were exposed to PGE1, dmPGE2 and indomethacin. Numbers and function of ISCs were assessed by analyzing Olfm4+ISCs. Intestinal protection of dmPGE2 was investigated on a 5-fluorouracil (5FU)-induced intestinal damage mouse model. The results showed that dmPGE2 treatment, but not PGE1, increased numbers of Olfm4+ISCs in dose- and time-dependent manners. Indomethacin treatment decreased numbers of Olfm4+ISCs. The beneficial effects of short-term dmPGE2 treatment on intestine were supported in a 5FU-induced intestinal damage model. Our data showed that 5FU treatment significantly decreased numbers of Olfm4+ISCs and goblet cells in intestine, which could be ameliorated by dmPGE2 treatment. dmPGE2 treatment accelerated the recovery of 5FU-induced ISC injury via increasing expression of cyclin D1 and D2 in intestine. Furthermore, dmPGE2 treatment-induced expression of cyclin D1 and D2 might be mediated by up-regulation of FOXM1 expression in intestine. These findings feature PGE2 as an effective protector against chemotherapy-induced intestinal damage.
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影响因子：
3.7
作者：
Olsen Hult LT;Kleiveland CR;Fosnes K;Jacobsen M;Lea T
通讯作者：
Lea T
影响因子：
4.7
作者：
Fan, Yang-Yi;Davidson, Laurie A.;Chapkin, Robert S.
通讯作者：
Chapkin, Robert S.
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
4.8
作者：
Fujino, H;Xu, W;Regan, JW
通讯作者：
Regan, JW
DOI：
10.1016/0090-6980(87)90052-9
发表时间：
1987-01-01
期刊：
PROSTAGLANDINS
影响因子：
--
作者：
HANSON, WR;DELAURENTIIS, K
通讯作者：
DELAURENTIIS, K