Synthetic studies of pseurotin A: preparation of an advanced lactam aldehyde intermediate.
Synthetic studies of pseurotin A: preparation of an advanced lactam aldehyde intermediate.
复制标题
DOI：
10.1039/b512701g
复制
发表时间：
2005-11
影响因子：
3.2
通讯作者：
Judith M. Mitchell;N. Finney
中科院分区：
文献类型：
--
作者：
Judith M. Mitchell;N. Finney
本论文完成了假鱼藤素A的内酰胺核的有效合成。该合成的关键特征包括串联氧化-环化以从炔酰胺前体形成内酰胺。尽管内酰胺醛与适当侧链的偶联不是有效的，但预期在较早阶段引入部分侧链应允许完成假黄菌素A的全合成。
An efficient synthesis of the lactam core of pseurotin A has been accomplished. Key features of this synthesis include a tandem oxidation-cyclization to form the lactam from an acetylenic amide precursor. Although coupling of a lactam aldehyde with an appropriate side chain was not effective, it is anticipated that incorporating a partial side chain at an earlier stage should permit completion of the total synthesis of pseurotin A.