Carbohydrate metabolism in pregnancy XVI: longitudinal estimates of the effects of pregnancy on D-(63H) glucose and D-(6-14C) glucose turnovers during fasting in the rat.
Carbohydrate metabolism in pregnancy XVI: longitudinal estimates of the effects of pregnancy on D-(63H) glucose and D-(6-14C) glucose turnovers during fasting in the rat.
复制标题
妊娠期碳水化合物代谢 XVI：纵向估计妊娠对大鼠禁食期间 D-(63H) 葡萄糖和 D-(6-14C) 葡萄糖周转的影响。
DOI：
10.1016/0026-0495(81)90185-2
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Freinkel,N
中科院分区：
文献类型：
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作者：
Ogata,ES;Metzger,BE;Freinkel,N
在妊娠第18、19和20天，我们测量了24小时禁食、清醒、不受约束的妊娠大鼠和非妊娠对照组的血糖浓度和葡萄糖周转率。通过同时平衡输注D-（6- 3 H）和D-（6- 14 C）葡萄糖来确保周转率测量，从而也可以确定产热循环。禁食24小时后，母亲的血糖“稳态”值在每一天都没有显著差异，并且这些浓度显著低于禁食24小时的非妊娠大鼠的血糖值。在妊娠18天，葡萄糖周转率与非妊娠值没有差异。相比之下，在妊娠19天和20天的大鼠中，禁食24小时后的葡萄糖周转值显著且进行性增加。营业额的增加与孕体的增长有关。在妊娠的所有3天内，D-（6- 14 C）葡萄糖和D-（6- 3 H）转换率之间的比值保持恒定（与未妊娠大鼠相同），表明葡萄糖再循环速率保持不变。这些纵向研究表明，导致怀孕期间饮食剥夺期间“加速饥饿”模式的因素可能随着怀孕的进展而变化。伴随禁食的血糖过度降低发生在总葡萄糖周转增加之前。这可能提供一种保存母体葡萄糖的潜在机制。由于葡萄糖的经胎盘转移是浓度依赖性的，因此早期建立循环葡萄糖的较低“稳态”可以减少胎儿这种关键营养素的损失程度。
We measured blood glucose concentrations and glucose turnover rates in 24 hr fasted, conscious, unrestrained pregnant rats and nongravid controls on days 18, 19, and 20 of gestation. Turnover measurements were secured with simultaneous equilibrium infusions of D-(6-3H) and D-(6-14C) glucose so that gluconeogenic recycling could also be determined. “Steady state” values for blood glucose in the mother after 24 hr of fasting did not significantly differ on each of the days, and these concentrations were significantly lower than the values in 24 hr fasted nongravid rats. At 18 days gestation, glucose turnover did not differ from nongravid values. By contrast, values for glucose turnover after 24 hr fasting increased significantly and progressively in the 19 and 20 day pregnant rats. The increase in turnover correlated with the increasing growth of the conceptus. The ratio between D-(6-14C) glucose and D-(6-3H) turnover remained constant (and the same as in the nongravid rats) during all 3 days of gestation suggesting that rates of glucose recycling remained unaltered. These longitudinal studies indicate that the factors contributing to the pattern of “accelerated starvation” during dietary deprivation in pregnancy may vary as pregnancy progresses. The exaggerated lowering of blood glucose which accompanies fasting occurs before total glucose turnover increases. This could provide a potential mechanism for conserving maternal glucose. Since transplacental transfer of glucose is concentration-dependent, the early establishment of a lower “steady state” for circulating glucose could diminish the magnitude of loss of this key nutrient to the fetus.