Non-traditional Dosing of Statins in Statin-Intolerant Patients-Is It Worth a Try?
Non-traditional Dosing of Statins in Statin-Intolerant Patients-Is It Worth a Try?
复制标题
DOI：
10.1007/s11883-014-0475-4
复制
发表时间：
2015-02-01
影响因子：
5.8
通讯作者：
Eckel, Robert H.
中科院分区：
文献类型：
--
作者：
Cornier, Marc-Andre;Eckel, Robert H.
在这篇手稿中，他汀类药物不耐受的三种表现将被涵盖。第一种是肌病，大多是主观的，肌痛的各种主诉通常会因运动、肌肉痉挛或虚弱而恶化，有时还与一种生物标记物--肌酸激酶(CK)的升高有关。一种罕见但严重的表现是横纹肌溶解。第二，肝脏毒性，与转氨酶的可逆性生化升高有关，很少与其他肝功能测试有关。最后，他汀类药物相关的中枢神经系统(CNS)毒性通常被定义为认知损害，这是非常罕见的，而且似乎是特殊的。他汀类药物的替代剂量将在新的降胆固醇指南中讨论和强调。非他汀类调脂疗法以及其他替代疗法也将被综述。
In this manuscript, three manifestations of statin intolerance will be covered. The first, myopathy, is mostly subjective with variable complaints of myalgias often worsened by exercise, muscle cramping or weakness, and at times associated with a biomarker, elevations in creatine kinase (CK). A rare but serious manifestation can be rhabdomyolysis. The second, liver toxicity, is associated with reversible biochemical increases in transaminases and rarely other liver function tests. Finally, statin-related central nervous system (CNS) toxicity typically defined as cognitive impairment is quite rare and appears to be idiosyncratic. Statin dose alternatives will then be discussed and highlighted in the setting of the new cholesterol-lowering guidelines. Non-statin lipid-altering therapies as well as other alternative therapies will also be reviewed.