The LDL receptor gene family, apolipoprotein B and cholesterol in embryonic development
The LDL receptor gene family, apolipoprotein B and cholesterol in embryonic development
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DOI：
10.1093/jn/129.2.473s
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发表时间：
1999-02-01
影响因子：
4.2
通讯作者：
Farese, RV
中科院分区：
文献类型：
--
作者：
Herz, J;Farese, RV
近年来，许多参与胆固醇合成、胆固醇的系统或细胞间转运或脂质代谢的基因被发现在胚胎发育过程中发挥重要作用，本文简要概述了这些基因，他们的分子功能，因为我们了解他们的日期和我们目前的解释可能的机制，遗传缺陷状态可能会影响发展胚胎发育，特别是中枢神经系统的形成。
In recent years, a number of genes that are involved in cholesterol synthesis, its systemic or intercellular transport or lipid metabolism in general have been found to play important roles during embryonic development, In this article, we present a brief overview of these genes, their molecular functions as we understand them to date and our current interpretation of possible mechanisms by which genetic deficiency states might affect the development of the embryo, in particular the formation of the central nervous system.