Epidemiology of acquisition and clearance of cervical human papillomavirus infection in women from a high-risk area for cervical cancer
Epidemiology of acquisition and clearance of cervical human papillomavirus infection in women from a high-risk area for cervical cancer
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DOI：
10.1086/315086
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发表时间：
1999-11-01
影响因子：
6.4
通讯作者：
Rohan, TE
中科院分区：
文献类型：
--
作者：
Franco, EL;Villa, LL;Rohan, TE
分析了巴西圣保罗参加妇幼保健项目的1425名低收入妇女宫颈人乳头瘤病毒（HPV）感染的获得和清除情况。每4个月采集一次标本，采用聚合酶链反应方案（MY09/11）进行检测，共有357例受试者至少一次呈阳性。每月新增感染1.3%，18个月后累计阳性38%。在177名入组阳性受试者中，12个月后只有35%的人仍然感染，非癌性类型的月清除率（12.2%，95%可信区间[CI]， 9.6-15.4）高于癌性HPV感染（9.5%,95% CI, 7.5-11.9），癌性类型的中位保留时间为8.1个月（95% CI, 7.8-8.3），非癌性HPV感染的中位保留时间为4.8个月（95% CI, 3.9-5.6）。非致瘤型和致瘤型的平均感染持续时间分别为8.2和13.5个月。尽管女性的年龄不影响致癌型感染的平均持续时间（13-14个月），但非致癌型感染在年轻(
Acquisition and clearance of cervical human papillomavirus (HPV) infection were analyzed among 1425 low-income women attending a maternal and child health program in Sao Paulo, Brazil. Specimens collected every 4 months were tested by a polymerase chain reaction protocol (MY09/11), In all, 357 subjects were positive at least once. There were 1.3% new infections per month, with 38% cumulative positivity after 18 months. Of 177 positive subjects at enrollment, only 35% remained infected after 12 months, The monthly clearance rate was higher for nononcogenic types (12.2%; 95% confidence interval [CI], 9.6-15.4) than for oncogenic HPV infections (9.5%; 95% CI, 7.5-11.9), Median retention times were 8.1 months (95% CI, 7.8-8.3) for oncogenic types and 4.8 months (95% CI, 3.9-5.6) for nononcogenic HPV infections. The mean infection durations were 8.2 and 13.5 months for nononcogenic and oncogenic types, respectively. Although a woman's age did not affect mean duration for oncogenic types (13-14 months), nononcogenic-type infections lasted longer (10.2 months) among younger (