Maternal Depression and Epstein-Barr Virus Reactivation in Early Pregnancy
Maternal Depression and Epstein-Barr Virus Reactivation in Early Pregnancy
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DOI：
10.1097/aog.0b013e31820f3a30
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发表时间：
2011-04-01
影响因子：
7.2
通讯作者：
Boggess, Kim A.
中科院分区：
文献类型：
--
作者：
Haeri, Sina;Johnson, Nell;Boggess, Kim A.
目的：最近的证据表明，由于细胞免疫反应降低，爱泼斯坦-巴尔病毒再激活和慢性应激之间存在联系。产妇抑郁症使10%至20%的怀孕复杂化，并伴有压力。我们试图估计与抑郁症在pregnancy.METHODS：在这项队列研究中，EB病毒再激活的患病率进行了比较，100名孕妇与抑郁症在怀孕前和计算机生成的参考组的100名健康女性不知道抑郁症。我们只纳入了那些在当前怀孕期间有精神障碍诊断和统计手册抑郁症诊断记录的妇女。分析血清样品中EB病毒衣壳抗原、核抗原和早期抗原抗体的存在。爱泼斯坦-巴尔病毒再激活的定义是存在病毒壳体抗原或核抗原免疫球蛋白（IG）G，沿着早期抗原IgG、病毒壳体抗原IgM或早期抗原IgG和病毒壳体抗原IgM。结果：两组产妇的人口统计学资料相似，除了年龄较大（34.1与32.7岁相比，P= 0.05），以及抑郁个体中较低的体重指数（27.3与28.9相比，P= 0.03）。95%的妇女对爱泼斯坦-巴尔病毒呈血清阳性。与参考参与者相比，患有抑郁症的女性更容易发生EB病毒再激活（48%比30%，P= 0.01）。在控制了潜在的混杂因素后，Epstein-Barr病毒再激活仍然与母亲抑郁症相关（调整后的比值比为1.97，95%置信区间为1.10-3.77，P= 0.03）。结论：抑郁症妇女的Epstein-Barr病毒再激活患病率较高，可能是由于压力增加。（Obstet Gynecol 2011;117：862-6）DOI：10.1097/AOG.0b013e31820f3a30
OBJECTIVE: Recent evidence suggests a link between Epstein-Barr virus reactivation and chronic stress due to decreased cellular immune responses. Maternal depression complicates 10% to 20% of pregnancies and is accompanied by stress. We sought to estimate the association of Epstein-Barr virus reactivation with depression in pregnancy.METHODS: In this cohort study, prevalence of Epstein-Barr virus reactivation was compared between 100 pregnant women with depression before pregnancy and a computer-generated referent group of 100 healthy women not known to be depressed. We included only those women with documented Diagnostic and Statistical Manual of Mental Disorders depression diagnoses in the current pregnancy. Serum samples were analyzed for presence of Epstein-Barr virus viral capsid antigen, nuclear antigen, and early antigen antibodies. Epstein-Barr virus reactivation was defined by presence of viral capsid antigen or nuclear antigen immunoglobulin (Ig) G, along with early antigen IgG, viral capsid antigen IgM, or both early antigen IgG and viral capsid antigen IgM.RESULTS: Maternal demographics were similar between the groups except for older age (34.1 compared with 32.7 years, P=.05), and lower body mass index (27.3 compared with 28.9, P=.03) among the depressed individuals. Ninety-five percent of the women were seropositive for Epstein-Barr virus. Women with depression were more likely to have Epstein-Barr virus reactivation (48% compared with 30%, P=.01) when compared with referent participants. Epstein-Barr virus reactivation remained associated with maternal depression (adjusted odds ratio 1.97, 95% confidence interval 1.10-3.77, P=.03) after controlling for potential confounders.CONCLUSION: Women with depression have higher prevalence of Epstein-Barr virus reactivation, possibly due to increased stress. (Obstet Gynecol 2011;117:862-6) DOI: 10.1097/AOG.0b013e31820f3a30