Hearing Loss and Congenital CMV Infection: A Systematic Review
Hearing Loss and Congenital CMV Infection: A Systematic Review
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DOI：
10.1542/peds.2014-1173
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发表时间：
2014-11-01
期刊：
影响因子：
8
通讯作者：
Dhooge, Ingeborg
中科院分区：
文献类型：
--
作者：
Goderis, Julie;De Leenheer, Els;Dhooge, Ingeborg
背景与目的：先天性巨细胞病毒（cCMV）感染引起的听力损失最早见于1964年。今天，cCMV是儿童非遗传性感音神经性听力损失的最常见原因。我们的目的是提供cCMV相关听力损失患病率的概述，更好地定义cCMV相关听力损失的性质，并调查cCMV感染在听力受损儿童中的重要性。方法：两名评审员独立使用Medline和手动检索合格研究和综述文章的参考文献，选择cCMV感染儿童的队列研究，并进行听力学随访。结果：共纳入37项研究：10项基于人群的自然史研究，14项纵向队列研究，13项回顾性研究。发达国家的cCMV患病率为0.58%（95%置信区间，0.41-0.79）。在这些新生儿中，12.6%（95%置信区间，10.2-16.5）将经历听力损失：3名有症状儿童中有1名，10名无症状儿童中有1名。在有症状的儿童中，大多数是双侧丢失;在无症状的儿童中，单侧丢失占主导地位。在这两个群体中，听力损失主要是严重到严重。听力损失可能会延迟发作，并且不稳定，有波动和进展。在听力受损的儿童中，cCMV是10%至20%的病原体。尽管有严格的选择标准，一些异质性之间被发现选定的study.CONCLUSIONS：这个系统的审查强调了cCMV作为儿童感音神经性听力损失的原因的重要性。
BACKGROUND AND OBJECTIVE: Hearing loss caused by congenital cytomegalovirus (cCMV) infection was first observed in 1964. Today cCMV is the most common cause of nonhereditary sensorineural hearing loss in childhood. Our objective was to provide an overview of the prevalence of cCMV-related hearing loss, to better define the nature of cCMV-associated hearing loss, and to investigate the importance of cCMV infection in hearing-impaired children.METHODS: Two reviewers independently used Medline and manual searches of references from eligible studies and review articles to select cohort studies on children with cCMV infection with audiological follow-up and extracted data on population characteristics and hearing outcomes.RESULTS: Thirty-seven studies were included: 10 population-based natural history studies, 14 longitudinal cohort studies, and 13 retrospective studies. The prevalence of cCMV in developed countries is 0.58% (95% confidence interval, 0.41-0.79). Among these newborns 12.6% (95% confidence interval, 10.2-16.5) will experience hearing loss: 1 out of 3 symptomatic children and 1 out of 10 asymptomatic children. Among symptomatic children, the majority have bilateral loss; among asymptomatic children, unilateral loss predominates. In both groups the hearing loss is mainly severe to profound. Hearing loss can have a delayed onset, and it is unstable, with fluctuations and progression. Among hearing-impaired children, cCMV is the causative agent in 10% to 20%. Despite strict selection criteria, some heterogeneity was found between selected studies.CONCLUSIONS: This systematic review underscores the importance of cCMV as a cause of sensorineural hearing loss in childhood.