Prevalence and Risk Factors for the Development of Nonalcoholic Fatty Liver Disease in a Nonobese Chinese Population: the Zhejiang Zhenhai Study
Prevalence and Risk Factors for the Development of Nonalcoholic Fatty Liver Disease in a Nonobese Chinese Population: the Zhejiang Zhenhai Study
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非肥胖中国人群中非酒精性脂肪肝的患病率和危险因素：浙江镇海研究
DOI：
10.1038/ajg.2013.104
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发表时间：
2013-08-01
影响因子：
9.8
通讯作者：
Li, Youming
中科院分区：
文献类型：
--
作者：
Xu, Chengfu;Yu, Chaohui;Li, Youming
结论：在非肥胖成人中发生非酒精性脂肪性肝病（NAFLD）的确切患病率和危险因素尚不清楚。本研究的目的是调查中国非肥胖人群中NAFLD的患病率及其发展的危险因素。方法：首先通过横断面研究调查中国非肥胖人群（体重指数（BMI）< 25 kg/m2）中NAFLD的患病率及其相关因素，然后通过随后的5年前瞻性随访分析同一人群中NAFLD发展的危险因素。基线评估显示NAFLD的患病率为7.27%。共有5，562名基线时无NAFLD的受试者完成了随访研究，494名（8.88%）在5年随访期间发生了NAFLD。进一步的分析显示，年龄，性别，体重指数，腰围，甘油三酯，高密度脂蛋白（HDL）胆固醇，血尿酸，血红蛋白，血小板计数与NAFLD的存在和发展独立相关。结论：NAFLD在中国非肥胖人群中普遍存在，并有相当比例的受试者在5年的随访期内发展为NAFLD。应特别关注非肥胖受试者中与NAFLD的存在和发展相关的因素，以改善NAFLD的预防和管理。
OBJECTIVES:The precise prevalence and risk factors for the development of nonalcoholic fatty liver disease (NAFLD) in nonobese adults remains unclear. The objective of this study was to investigate the prevalence of NAFLD and risk factors for its development in a nonobese Chinese population.METHODS:We firstly investigated the prevalence and factors associated with the presence of NAFLD in nonobese (body mass index (BMI)< 25 kg/m 2) Chinese subjects via a cross-sectional study, and then analyzed the risk factors for the development of NAFLD via a subsequent prospective 5-year follow-up of the same population.RESULTS:A total of 6,905 nonobese subjects were enrolled in the cross-sectional study. Baseline evaluation revealed that the prevalence of NAFLD was 7.27%. A total of 5,562 subjects who were free of NAFLD at baseline completed the follow-up study, and 494 (8.88%) had developed NAFLD during the 5-year follow-up. Further analyses revealed that age, gender, BMI, waist circumference, triglyceride, high-density lipoprotein (HDL) cholesterol, serum uric acid, hemoglobin, and platelet count were independently associated with the presence and development of NAFLD.CONCLUSIONS:NAFLD is prevalent in the nonobese Chinese population, and a substantial proportion of subjects developed NAFLD over the 5-year follow-up period. Special attention should be paid to the factors associated with the presence and development of NAFLD in nonobese subjects, to improve prevention and management of NAFLD.