Innovative approaches for enhancing cancer gene therapy.
Innovative approaches for enhancing cancer gene therapy.
复制标题
DOI：
--
复制
发表时间：
2013-05
影响因子：
1.4
通讯作者：
Shilpa Bhatia;M. E. Menezes;Swadesh K. Das;L. Emdad;S. Dasgupta;Xiang-Yang Wang;D. Sarkar;P. Fisher
中科院分区：
文献类型：
--
作者：
Shilpa Bhatia;M. E. Menezes;Swadesh K. Das;L. Emdad;S. Dasgupta;Xiang-Yang Wang;D. Sarkar;P. Fisher
基因治疗为多种遗传性和非遗传性疾病的治疗干预提供了一个新的平台。随着该领域的最新发展，出现了各种各样的病毒和非病毒载体，可以将遗传有效载荷传递到靶细胞。然而，非靶向递送转基因往往导致不良的效果，低肿瘤转导，降低治疗指数。在这篇综述中，我们重点介绍了一些新的方法，这些方法可以用来应对该领域目前的挑战，并在不久的将来将癌症基因治疗的潜力从“实验室”转化为“临床”。
Gene therapy provides a novel platform for therapeutic intervention of several genetic and non-genetic disorders. With the recent developments in the field, a wide variety of viral and non-viral vectors have emerged that can deliver genetic payloads to target cells. However, non-targeted delivery of transgenes often results in undesirable effects, low tumor transduction, and reduced therapeutic index. In this review, we focus on some of the novel approaches that can be used to meet the present challenges in the field and translate the potential of cancer gene therapy from 'bench to bedside' in the near future.