Eosinophilic annular erythema is clinically characterized by central pigmentation reflecting basal melanosis: a clinicopathological study of 10 cases
Eosinophilic annular erythema is clinically characterized by central pigmentation reflecting basal melanosis: a clinicopathological study of 10 cases
复制标题
DOI：
10.1111/jdv.14350
复制
发表时间：
2017-11-01
影响因子：
9.2
通讯作者：
Shimizu, H.
中科院分区：
文献类型：
--
作者：
Nakazato, S.;Fujita, Y.;Shimizu, H.
背景嗜酸性环状红斑（EAE）已被提出作为一个临床实体来描述与组织嗜酸性粒细胞增多相关的环状皮肤病变。然而，尚未对EAE的组织病理学进行系统研究，目的探讨EAE的临床病理学特征。方法回顾性分析10例EAE患者的临床资料，并结合文献复习，总结其临床病理特点。结果10例临床表现为环状或类环状病变，组织病理学检查示真皮内嗜酸性粒细胞浸润的患者中，9例（10/10例呈环形，内侧有色素沉着。仅1例患者出现血嗜酸性粒细胞增多。组织学上，9例观察到基底黑变病。嗜酸性粒细胞浸润仅限于真皮层9例。全身性皮质类固醇治疗的患者往往表现出较少的复发比那些治疗局部corticosteroids.Limitations我们的研究的主要限制是少数patients.Conclusion皮肤活检时，应进行EAE是可疑的，即使在没有血液嗜酸性粒细胞增多症的情况下。局限于真皮的基底黑变病和组织嗜酸性粒细胞增多提示EAE的诊断。我们推荐外用皮质类固醇作为EAE的初始治疗。
Background Eosinophilic annular erythema (EAE) has been proposed as a clinical entity to describe annular skin lesions associated with tissue eosinophilia. However, systematic investigations on the histopathology of EAE have not been performed, and useful histopathological findings for diagnosis of EAE remain unknown.Objective The aim of this study was to investigate the clinicopathological features of EAE.Methods We retrospectively studied 10 patients at our hospital during a 5-year span who clinically showed annular or figurate lesions and histopathologically exhibited eosinophilic infiltration in the dermis.Results Nine of the 10 cases had annular lesions with pigmentation on the interior side. Blood eosinophilia was found in only one patient. Histopathologically, basal melanosis was observed in nine cases. Infiltration of eosinophils was confined to the dermis in nine cases. Patients treated with systemic corticosteroid tended to show less recurrence than those treated with topical corticosteroid.Limitations The main limitation of our study is the small number of patients.Conclusion Skin biopsy should be performed when EAE is suspected, even in cases without blood eosinophilia. Basal melanosis and tissue eosinophilia confined to the dermis suggest the diagnosis of EAE. We recommend topical corticosteroids as the initial treatment for EAE.