Cardiovascular and renal effects of isoproterenol infusions in young swine.
Cardiovascular and renal effects of isoproterenol infusions in young swine.
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异丙肾上腺素输注对幼猪的心血管和肾脏影响。
DOI：
10.1159/000241779
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Frasier,ID
中科院分区：
文献类型：
--
作者：
Buckley,NM;Brazeau,P;Charney,AN;Cabili,S;Feldman,G;Garvey,M;Frasier,ID
静脉内（i. v.）和动脉内（i.a.）在17只用戊巴比妥麻醉的两周龄猪中评价了异丙肾上腺素（ISP，0.1-0.2 μg/kg/min）的输注。测定所有动物各肾的肾小球滤过率（GFR）以及左肾的血流量和血管阻力（RVR）。在静脉注射ISP的8只动物中，右心室压力和dP/dtmax也通过开胸术测定。在9只动物中，i.a.在左肾原位恒流灌注稳定后。在i. v.输注ISP期间，正性肌力和变时性作用以及动脉压降低得以维持;肾血流量和GFR增加，RVR降低。在内部检查期间。在恒定流灌注的肾脏中输注ISP，尽管到达肾脏的药物的有效浓度较高，但观察到RVR和GFR的相似变化。我们的结论是，在出生后肾脏发育的这个阶段，输注强心剂量的ISP降低RVR，并产生GFR的小幅增加。
The cardiovascular and renal effects of intravenous (i.v.) and intra-arterial (i.a.) infusions of isoproterenol (ISP, 0.1–0.2 μg/kg/min) were evaluated in 17 two-week-old swine anesthetized with pentobarbital. The glomerular filtration rate (GFR) of each kidney and blood flow and vascular resistance (RVR) of the left kidney were determined in all animals. In the 8 animals given ISP i.v., right ventricular pressure and dP/dtmaxwere also determined via a thoracotomy. In 9 animals, ISP was given i.a. after stabilization of constant-flow perfusion of the left kidney in situ. During i.v. infusion of ISP, the positive inotropic and chronotropic effects and the decrease in arterial pressure were maintained; renal blood flow and GFR increased and RVR decreased. During i.a. infusion of ISP in the constant-flow perfused kidney, similar changes in RVR and GFR were observed despite the higher effective concentrations of drug reaching the kidney. We conclude that, at this stage of postnatal renal development, the infusion of cardiotonic doses of ISP lowers RVR and produces a small increase in GFR.