Noxious heat evokes stronger sharp and annoying sensations in women than men in hairy skin but not in glabrous skin
Noxious heat evokes stronger sharp and annoying sensations in women than men in hairy skin but not in glabrous skin
复制标题
DOI：
10.1016/j.pain.2010.06.026
复制
发表时间：
2010-11-01
期刊：
影响因子：
7.4
通讯作者：
Davis, Karen D.
中科院分区：
文献类型：
--
作者：
Hashmi, Javeria A.;Davis, Karen D.
短暂的毒热会引起女性比男性更强烈的疼痛；然而，在有毛和无毛的皮肤上引起的痛感强度的性别差异尚不清楚。据推测，无毛皮肤缺乏A型三角洲伤害性感受器，这种伤害性感受器是热刺激的尖锐感觉的基础。因此，我们评估了有毛和无毛的皮肤是否具有不同的有害热诱发疼痛特性，以及在这些诱发疼痛中是否存在性别差异。我们对16名男性和16名女性的足部背侧和腹侧施加了长时间(30 S)斜坡式伤害性热刺激。对每个受试者的刺激进行了校准，以唤起50/100的峰值疼痛幅度。受试者在不同的跑步中对疼痛、烦恼、灼热、尖锐、刺痛和割伤的感觉进行持续的在线评级。结果表明，性别和皮肤类型都会影响有害的热诱发感觉。具体地说，女性对多毛皮肤引起的尖锐感觉和烦恼的评分明显高于男性。无毛皮肤有尖锐、刺痛和割伤的感觉，但这些感觉在有毛的皮肤比无毛皮肤更大；这种影响只在女性身上发生。无毛皮肤的尖锐感和烦躁感无性别差异。这些发现表明，女性在有毛的皮肤上比在无毛的皮肤上更容易产生尖锐的感觉，而尖锐的感觉和烦恼在女性多毛皮肤引起的疼痛中起着突出的作用。(C)2010年国际疼痛研究协会。爱思唯尔出版公司版权所有。
Brief noxious heat evokes more intense pain in women than in men; however, sex differences in the intensity of pain sensations evoked in hairy and glabrous skins are not clearly understood. Glabrous skin putatively lacks the type of A-delta nociceptors that underlie heat-evoked sharp sensation. Therefore, we assessed whether noxious heat-evoked pain qualities differed for hairy and glabrous skins and whether sex differences exist in these evoked pains. We applied a prolonged (30 s) ramped noxious heat stimulus to the dorsal and ventral aspects of the feet of 16 males and 16 females. Stimuli were calibrated in each subject to evoke a peak pain magnitude of 50/100. Subjects provided continuous online ratings of pain, annoyance, burning, sharp, stinging and cutting sensations in separate runs. The results indicate that both sex and skin type impact noxious heat-evoked sensations. Specifically, ratings of sharp sensations and annoyance evoked in hairy skin were significantly more intense in women than in men. Sharp, stinging and cutting sensations were evoked in glabrous skin, but the magnitude of these sensations was greater in hairy skin than glabrous skin; an effect only in females. Also, there was no sex difference in sharp sensation and annoyance in glabrous skin. These findings suggest that sharp sensations are evoked more prominently in hairy than in glabrous skin of women and that sharp sensations and annoyance play a prominent role in mediating aspects of pain evoked from hairy skin in women. (C) 2010 International Association for the Study of Pain. Published by Elsevier B. V. All rights reserved.