Using automated extraction of hepatitis B tests for surveillance: evidence of decreasing incidence of acute hepatitis B in England
Using automated extraction of hepatitis B tests for surveillance: evidence of decreasing incidence of acute hepatitis B in England
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DOI：
10.1017/s0950268811001683
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发表时间：
2012-06-01
影响因子：
4.2
通讯作者：
Ramsay, M. E.
中科院分区：
文献类型：
--
作者：
Brant, L. J.;Hurrelle, M.;Ramsay, M. E.
在英格兰监测急性乙肝对于估计发病率、确定传播途径和为公共卫生行动提供信息是必要的。在这里，我们描述了一个自动化的过程，以提取2002至2008年间英国哨兵实验室中乙肝感染标志物检测的信息。结果数据被用来识别急性感染的个人，描述他们的特征，并估计感染的发生率。三分之二的急性感染是男性。报告的主要风险是异性接触和注射吸毒。年发病率估计为1.3/10万人年(男性和女性分别为1.7和0.6)，并逐年下降。乙肝标志物的自动提取，包括可用的定量结果，可以帮助更准确地对乙肝病毒状态进行分类，以便进行监测。英国的乙肝发病率处于近年来的最低水平。
Surveillance of acute hepatitis B in England is necessary to estimate incidence, determine routes of transmission and inform public health actions. Here we describe an automated process to extract information on testing for markers of hepatitis B infection in English sentinel laboratories between 2002 and 2008. The resulting data were used to identify individuals with acute infections, describe their characteristics and estimate the incidence of infection. Two-thirds of acute infections were in males. Heterosexual exposure and injecting drug use were the main risks reported. Annual incidence was estimated at 1.3/100 000 person-years overall (1.7 and 0.6 for males and females, respectively) and declined each year. Automated extraction of hepatitis B markers, including quantitative results where available, can help to classify HBV status more accurately for surveillance. HBV incidence in England is at its lowest level in recent years.