Expression of fatty acid synthase, ErbB2 and Ki-67 in head and neck squamous cell carcinoma. A clinicopathological study
Expression of fatty acid synthase, ErbB2 and Ki-67 in head and neck squamous cell carcinoma. A clinicopathological study
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DOI：
10.1016/j.oraloncology.2004.01.004
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发表时间：
2004-08-01
期刊：
影响因子：
4.8
通讯作者：
Graner, E
中科院分区：
文献类型：
--
作者：
Silva, SD;Agostini, M;Graner, E
脂肪酸合成酶（FAS）是一种多功能酶，负责使用乙酰辅酶A和丙二酰辅酶A作为底物合成饱和脂肪酸。在几种人类恶性肿瘤中报告了FAS的过表达，并建议作为潜在的预后因素。ErbB 2（Her-2/neu）是ErbB受体家族的跨膜酪氨酸激酶成员，已知在多种肿瘤中过表达，最近显示可调节乳腺上皮细胞系中FAS的产生。本文采用免疫组化方法检测了62例头颈部鳞状细胞癌（HNSCC）组织中FAS、ErbB 2和增殖标志物Ki-67的表达。大约78%的病例在细胞膜上对FAS或ErbB 2呈阳性，并且显示FAS高表达的70%的肿瘤也对ErbB 2呈强阳性（Fisher精确检验，p = 0.01）。FAS和ErbB 2的免疫标记在组织学分化良好的病变中更强。此外，Ki-67表达与不良预后显著相关（对数秩检验，p = 0.03）。综上所述，本研究结果提示ErbB 2调节HNSCC中FAS的表达，并指出Ki-67是这些肿瘤的有用预后标志物。(C)2004爱思唯尔有限公司保留所有权利。
Fatty acid synthase (FAS) is a multifunctional enzyme responsible for the synthesis of saturated fatty acids using acetyl-CoA and malonyl-CoA as substrates. Overexpression of FAS has been reported in several human malignancies and suggested as a potential prognostic factor. ErbB2 (Her-2/neu), a transmembrane tyrosine kinase member of the ErbB receptor family, is known to be overexpressed in a variety of tumors and was recently shown to regulate FAS production in breast epithelial cell lines. Herein we analyzed by immunohistochemistry the expression of FAS, ErbB2, and the proliferation marker Ki-67 in 62 head and neck squamous cell carcinoma (HNSCC) samples. Approximately 78% of the cases were positive for FAS or ErbB2 at the cell membrane and 70% of the tumors that showed a high expression of FAS were also strongly positive for ErbB2 (Fisher's exact test, p = 0.01). The immunolabeling for both FAS and ErbB2 was stronger in histologically well-differentiated lesions. Additionally, Ki-67 expression was significantly associated with a poor prognosis (log-rank test, p = 0.03). Taken together, the results presented here suggest that ErbB2 regulates FAS expression in HNSCC and point out Ki-67 as a useful prognostic marker for these tumors. (C) 2004 Elsevier Ltd. All rights reserved.