The molecular fingerprint of high grade serous ovarian cancer reflects its fallopian tube origin.
The molecular fingerprint of high grade serous ovarian cancer reflects its fallopian tube origin.
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DOI：
10.3390/ijms14046571
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发表时间：
2013-03-25
影响因子：
5.6
通讯作者：
Meyer T
中科院分区：
文献类型：
--
作者：
Kessler M;Fotopoulou C;Meyer T
高级别浆液性卵巢癌（High grade serous ovarian cancer，HGSC）是卵巢上皮性癌（epithelial ovarian cancer，EOC）中最常见、致死率最高的一种类型，其长期预后较差，这是由于多种因素的综合作用：晚期发现、巨大的转移潜力和对现有治疗药物产生耐药性的能力。此外，关于这种恶性肿瘤的病因一直存在相当大的争议。新的临床和分子生物学研究强烈表明，HGSC不是起源于卵巢表面，而是起源于邻近输卵管伞的上皮层。在本文中，我们总结的数据支持输卵管上皮细胞在HGSC的发展中的核心作用。具体而言，我们解决了在转化过程中调节的细胞途径和调节机制，以及在疾病进展过程中积累的遗传变化。输卵管粘膜和HGSC恶性组织之间的相似性保证了健康上皮中稳态机制的更密切分析，以阐明疾病发展的关键步骤。最后，我们强调了癌症干细胞（CSC）的识别和理解其生态位调节的重要性，以改善治疗策略。
High grade serous ovarian cancer (HGSC), the most lethal and frequent type of epithelial ovarian cancer (EOC), has poor long term prognosis due to a combination of factors: late detection, great metastatic potential and the capacity to develop resistance to available therapeutic drugs. Furthermore, there has been considerable controversy concerning the etiology of this malignancy. New studies, both clinical and molecular, strongly suggest that HGSC originates not from the surface of the ovary, but from the epithelial layer of the neighboring fallopian tube fimbriae. In this paper we summarize data supporting the central role of fallopian tube epithelium in the development of HGSC. Specifically, we address cellular pathways and regulatory mechanisms which are modulated in the process of transformation, but also genetic changes which accumulate during disease progression. Similarities between fallopian tube mucosa and the malignant tissue of HGSC warrant a closer analysis of homeostatic mechanisms in healthy epithelium in order to elucidate key steps in disease development. Finally, we highlight the importance of the cancer stem cell (CSC) identification and understanding of its niche regulation for improvement of therapeutic strategies.