Expression of V-domain immunoglobulin suppressor of T cell activation is associated with the advanced stage and presence of lymph node metastasis in ovarian cancer.
Expression of V-domain immunoglobulin suppressor of T cell activation is associated with the advanced stage and presence of lymph node metastasis in ovarian cancer.
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DOI：
10.3892/ol.2018.9059
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发表时间：
2018-09
期刊：
影响因子：
2.9
通讯作者：
Wang H
中科院分区：
文献类型：
--
作者：
Liao H;Zhu H;Liu S;Wang H
V域免疫球蛋白T细胞活化抑制因子（VISTA）是一种新的负性免疫检查点，属于B7家族。VISTA主要在造血细胞上表达并抑制T细胞增殖和细胞因子产生。VISTA的阻断已在某些鼠肿瘤模型中显示出有希望的结果。在本研究中，在65例卵巢癌（OC）患者的队列中进行肿瘤细胞、瘤内免疫细胞和血管内皮细胞上VISTA表达的免疫组织化学分析。使用Fisher精确检验评估VISTA表达与不同临床病理特征之间的相关性，并通过构建Kaplan-Meier曲线进行不同组的总生存分析。结果表明，肿瘤细胞或IC上VISTA的高表达与晚期肿瘤分期和淋巴结转移（LNM）的存在显著相关。然而，肿瘤细胞上VISTA高表达的病例百分比（24.6%）与IC上高表达的病例百分比（44.6%）相比有所下降。VISTA表达与5年总生存率之间无相关性，基于多变量考克斯回归分析，晚期疾病是不良预后的唯一独立预测因素。一般而言，VISTA表达随着疾病阶段和LNM的进展而增加，表明VISTA表达参与OC的进展。更重要的是，这些数据表明VISTA是OC的候选免疫靶点。
V-domain immunoglobulin suppressor of T cell activation (VISTA) is a novel negative immune checkpoint that belongs to the B7 family. VISTA is primarily expressed on hematopoietic cells and inhibits T cell proliferation and cytokine production. The blockade of VISTA has demonstrated promising results in certain murine tumor models. In the present study, an immunohistochemical analysis of VISTA expression on tumor cells, intratumoral immune cells and vascular endothelial cells was performed in a cohort of 65 patients with ovarian cancer (OC). The associations between VISTA expression and different clinicopathological characteristics were evaluated using Fisher's exact test, and the analysis of overall survival in different groups was performed by the construction of Kaplan-Meier curves. The results indicated that high expression of VISTA on tumor cells or ICs was significantly associated with advanced tumor stage and the presence of lymph node metastasis (LNM). However, the percentage of cases with high expression of VISTA on tumor cells (24.6%) was decreased compared with those with high expression on ICs (44.6%). There was no association between VISTA expression and the 5-year overall survival rate, and advanced-stage disease was the only independent predictor of poor prognosis based on multivariate Cox regression analysis. In general, VISTA expression increased with advanced disease stage and LNM, indicating that VISTA expression is involved in the progression of OC. More importantly, these data implicate VISTA as a candidate immunotherapeutic target in OC.
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影响因子：
11.2
作者：
Le Mercier I;Chen W;Lines JL;Day M;Li J;Sergent P;Noelle RJ;Wang L
通讯作者：
Wang L
DOI：
10.1084/jem.20100619
发表时间：
2011-03-14
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Wang L;Rubinstein R;Lines JL;Wasiuk A;Ahonen C;Guo Y;Lu LF;Gondek D;Wang Y;Fava RA;Fiser A;Almo S;Noelle RJ
通讯作者：
Noelle RJ
DOI：
10.1038/nrc3239
发表时间：
2012-03-22
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Pardoll DM
通讯作者：
Pardoll DM
DOI：
10.1097/pas.0b013e3181cf3d79
发表时间：
2010-03
期刊：
The American journal of surgical pathology
影响因子：
--
作者：
Kurman RJ;Shih IeM
通讯作者：
Shih IeM
影响因子：
4.7
作者：
Webb, John R.;Milne, Katy;Nelson, Brad H.
通讯作者：
Nelson, Brad H.