Recent Advances in Difluoromethylation Reaction
Recent Advances in Difluoromethylation Reaction
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DOI：
10.1002/chin.201619216
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发表时间：
2015-07
影响因子：
2.6
通讯作者：
Yang Lü;Chao Liu;Qing‐Yun Chen
中科院分区：
文献类型：
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作者：
Yang Lü;Chao Liu;Qing‐Yun Chen
在过去十年中，在有机化合物中加入各种含氟基团，特别是轻度氟化基团方面取得了令人印象深刻的进展。其中，在化合物中引入二氟甲基通常会产生许多特殊而重要的效应。已开发出两个主要策略：(1)将CF2H基团直接转移到目标分子中(直接二氟甲基化)；(2)在有机底物中引入官能化部分，然后将官能团转化为氢或氟原子(逐步二氟甲基化)。本文综述了近六年来选择性、直接和分步二氟甲基化方法的最新进展。
Impressive progress has been achieved during the past decade in the incorporation of various fluroinecontaining groups, especially lightly fluorinated groups, into organic compounds. Among them, the introduction of difluoromethyl group into a compound commonly brings about many special and important effects. Two major strategies have been developed: (1) direct transfer of a CF2H group into target molecules (direct difluoromethylation); (2) the introduction of a functionlized moiety into organic substrates followed by subsequent transformation of the functional group into hydrogen or fluorine atoms (stepwise difluoromethylation). This mini review summarizes the recent developments in the selective direct and stepwise difluoromethyaltion methods during the past six years.