Enantioselective Photolysis and Quantitative Chiral Analysis of Tryptophan Complexed With Alkali-Metalized L-Serine in the Gas Phase
Enantioselective Photolysis and Quantitative Chiral Analysis of Tryptophan Complexed With Alkali-Metalized L-Serine in the Gas Phase
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DOI：
10.1002/chir.22442
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发表时间：
2015-05-01
期刊：
影响因子：
2
通讯作者：
Hayakawa, Shigeo
中科院分区：
文献类型：
--
作者：
Fujihara, Akimasa;Maeda, Naoto;Hayakawa, Shigeo
The enantioselective photolysis of a cold gas-phase noncovalent complex of tryptophan with alkali-metalized L-serine, M+(L-Ser)(Trp) (M = Na and Li), was examined using a tandem mass spectrometer containing a variable-temperature ion trap. CO2 loss from Trp in the clusters was enantiomerically selective in ultraviolet excitation with linearly polarized light. M+(L-Ser) promoted the enantioselective photolysis of Trp as a chiral auxiliary. The enantioselective photolysis of the D-enantiomer was applied to a quantitative chiral analysis, in which the optical purity of tryptophan could be determined by measuring the relative abundance ratio R of the enantioselective CO2 loss to the chiral-independent evaporation of L-Ser in a single photodissociation mass spectrum of M+(L-Ser)(Trp). Chirality 27:349-352, 2015. (c) 2015 Wiley Periodicals, Inc.
