Renal cell carcinoma in children: a single institution's experience.
Renal cell carcinoma in children: a single institution's experience.
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儿童肾细胞癌：单个机构的经验。
DOI：
10.1002/mpo.2950230107
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
R. Kodet
中科院分区：
文献类型：
--
作者：
T. Eckschlager;R. Kodet
15 年来，7 名肾细胞癌 (RCC) 患者在布拉格小儿肿瘤科接受了治疗。诊断时的平均年龄为 8 岁零 9 个月。组织学检查显示，5 个肿瘤为透明细胞型，具有混合管状、乳头状和实性形态；一种肿瘤是纯粹的乳头状嗜酸性粒细胞型，另一种是由透明的嗜酸性细胞组成。五名患者接受了化疗，其中四名患者还接受了放疗。最短随访时间为 2 年，四名患者没有疾病证据。这四位患者均处于临床 I 期或 II 期。两名 III 期患者死于转移性疾病。一名患者在手术中因肺部肿瘤栓塞死亡。处于较低临床阶段的患者的肿瘤诊断和治疗似乎对儿童肾细胞癌具有良好的预后影响。尽管迄今为止治疗的患者数量有限，但以长春花碱作为其中一种药物的联合化疗以及可能的额外免疫疗法似乎具有有希望的结果。
Seven patients with renal cell carcinomas (RCC) were treated at the Department of Pediatric Oncology in Prague over a period of 15 years. The average age at diagnosis was 8 years 9 months. Histology review showed five tumors to be of clear cell type with mixed tubular, papillary, and solid patterns; one tumor was purely papillary eosinophilic type and one was composed of clear and eosinophilic cells. Five patients received chemotherapy and four of them also received radiotherapy. Four patients are without evidence of disease with a minimal follow-up period of 2 years. These four were all clinical stage I or II. Two stage III patients died of metastatic disease. One patient died of tumor emboli to the lungs at operation. Tumor diagnosis and treatment of the patients in the lower clinical stages seem to have a favorable prognostic impact in childhood RCC. Combined chemotherapy with vinblastine as one of the agents, and possibly additional immunotherapy, appears to have promising results, although the number of patients treated thus far is limited.
维尔姆斯肿瘤的年龄分布：来自国家维尔姆斯肿瘤研究的报告。
影响因子：
11.2
作者：
Breslow,N;Beckwith,JB;Ciol,M;Sharples,K
通讯作者：
Sharples,K