Examining the characteristics and beliefs of hydroxyurea users and nonusers among adults with sickle cell disease
Examining the characteristics and beliefs of hydroxyurea users and nonusers among adults with sickle cell disease
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DOI：
10.1002/ajh.21883
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发表时间：
2011-01-01
影响因子：
12.8
通讯作者：
Lanzkron, Sophie
中科院分区：
文献类型：
--
作者：
Haywood, Carlton, Jr.;Beach, Mary Catherine;Lanzkron, Sophie
镰状细胞病(SCD)患者对羟基脲(HU)治疗的态度可能是导致HU在美国利用不足的原因之一，但我们对这些态度的了解有限。我们调查了94名成年SCD患者的态度和信念，比较了从未使用HU(n=37)、以前使用HU(n=23)和目前正在使用HU(n=34)的患者。70%的HU当前使用者报告药物有一定程度的改善(“一般”或“非常大”)，80%的人报告副作用很小或没有问题。57%的前用户报告称，服用胡舒立的时间不到6个月，最常报告的停用胡舒立的原因是“医生推荐”或“不喜欢它给我的感觉”。50%的Never用户报告从任何来源都没有收到关于Hu的信息，85%的Never用户认为如果他们服用HU，他们不会得到任何改善。需要更深入地了解患者对HU利用的看法，作为多管齐下的努力的一部分，以对抗其在SCD治疗中的未充分利用。
The attitudes of patients with sickle cell disease (SCD) toward the use of hydroxyurea (HU) therapy may contribute to the underutilization of HU in the United States, yet our understanding of these attitudes is limited. We examined the attitudes and beliefs of 94 adult SCD patients, comparing those who never used HU (n = 37), formerly used HU (n = 23), and were currently using HU (n = 34). Seventy percent of current HU users reported some level of improvement from the drug ("average" or "very much") and 80% reported little or no trouble from side effects. Fifty-seven percent of former users reported taking HU for less than 6 months, with "doctor's recommendation," or "not liking the way it made me feel" given as the most commonly reported reasons for stopping HU. Fifty percent of the never users reported receiving no information about HU from any source, and 85% of the never users thought that they would receive no improvement if they were to take HU. A deeper understanding of patient perspectives toward HU utilization is required as part of multipronged efforts to combat its underutilization in the treatment of SCD.