Functional connectivity change across multiple cortical networks relates to episodic memory changes in aging
Functional connectivity change across multiple cortical networks relates to episodic memory changes in aging
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DOI：
10.1016/j.neurobiolaging.2015.08.020
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发表时间：
2015-12-01
影响因子：
4.2
通讯作者：
Walhovd, Kristine B.
中科院分区：
文献类型：
--
作者：
Fjell, Anders M.;Sneve, Markus H.;Walhovd, Kristine B.
当代认知神经科学关于衰老的一项主要任务是解释为什么情景记忆会衰退。静息状态功能连接性(RsFC)的改变可能是导致功能降低的一种机制。我们通过3项研究解决了这个问题。在研究1中，119名健康的参与者(20-83岁)被跟踪了3.5年，进行了言语回忆测试和磁共振成像。与萎缩无关，回忆变化与解剖学上广泛分布的区域rsFC的变化有关。观察到了显著的年龄效应，因为rsFC与记忆之间的正相关关系是老年参与者的特征，而在年轻人和中年人中则是负相关关系。这表明rsFC变化的认知后果在年龄上并不稳定。在研究2和研究3中，通过使用模拟模型(研究2)和横断面实验再认记忆任务(研究3)，复制了rsFC-记忆关系的年龄依赖差异。总而言之，记忆变化与rsFC的改变以一种年龄相关的方式相关，未来的研究需要详细说明年龄变化关系背后的机制。(C)2015 Elsevier Inc.保留所有权利。
A major task of contemporary cognitive neuroscience of aging is to explain why episodic memory declines. Change in resting-state functional connectivity (rsFC) could be a mechanism accounting for reduced function. We addressed this through 3 studies. In study 1, 119 healthy participants (20-83 years) were followed for 3.5 years with verbal recall testing and magnetic resonance imaging. Independent of atrophy, recall change was related to change in rsFC in anatomically widespread areas. Striking ageeffects were observed in that a positive relationship between rsFC and memory characterized older participants while a negative relationship was seen among the younger and middle-aged. This suggests that cognitive consequences of rsFC change are not stable across age. In study 2 and 3, the age-dependent differences in rsFC-memory relationship were replicated by use of a simulation model (study 2) and by a cross-sectional experimental recognition memory task (study 3). In conclusion, memory changes were related to altered rsFC in an age-dependent manner, and future research needs to detail the mechanisms behind age-varying relationships. (C) 2015 Elsevier Inc. All rights reserved.