Chronic parasite infections cause immune changes that could affect successful vaccination
Chronic parasite infections cause immune changes that could affect successful vaccination
复制标题
DOI：
10.1016/j.pt.2008.02.009
复制
发表时间：
2008-06-01
影响因子：
9.6
通讯作者：
Bentwich, Zvi
中科院分区：
文献类型：
--
作者：
Borkow, Gadi;Bentwich, Zvi
在地球蠕虫高流行地区进行任何疫苗接种时，必须考虑几个重要问题。如果不考虑免疫背景，感染地蠕虫的人群的免疫接种可能是次优的。免疫调节和驱虫可能是有效保护性疫苗接种的关键。此外，还需要进一步的动物模型和临床研究来解决这些问题。最近的一份报告强调了这些问题的重要性，并强调了几项疫苗接种研究，在这些研究中，感染线虫的小鼠或猪未能产生有效的保护性免疫反应。
Several important issues must be considered when performing any vaccination in areas with high prevalence of geohelminths. Immunization of populations infected with geohelminths could be sub-optimal if the immune background is not taken into consideration. Immune modulation and deworming might be essential for effective protective vaccination. In addition, further animal models and clinical studies addressing these issues are required. Underscoring the importance of these issues, a recent report has highlighted several vaccination studies in which nematode-infected mice or pigs failed to mount efficient protective immune responses.