Exposure of low-concentration arsenic-initiated inflammation and autophagy in rat lungs
Exposure of low-concentration arsenic-initiated inflammation and autophagy in rat lungs
复制标题
低浓度砷暴露引起的大鼠肺部炎症和自噬
DOI：
10.1002/jbt.22334
复制
发表时间：
2019
影响因子：
3.6
通讯作者：
Wang Suhua
中科院分区：
文献类型：
--
作者：
Zhao Yuhang;Su Xin;Gao Yanrong;Yin Haijing;Wang Li;Qiao Rui;Wang Suhua
慢性饮水砷暴露是一个世界性的问题，已导致多种疾病。肺是砷的第一靶器官，暴露于砷可引起肺部炎症、自噬，甚至诱发肿瘤的发生。在这里，我们测试了低浓度砷暴露在大鼠肺中的结果。在这项研究中观察了组织变化、炎症、自噬和其他生理反应。结果显示，通过饮水摄入低浓度亚砷酸盐可在肺部引发自噬和炎症，但高浓度暴露会产生微弱的自噬反应并加剧炎症，有可能出现慢性炎症环境，继而发生肿瘤。
Chronic arsenic exposure through water intake is a worldwide issue, which has caused many diseases. Lungs are the first target organ of arsenic and lung inflammation, autophagy, and even the onset of tumors can be induced by arsenic exposure. Here, we tested the outcome of low‐concentration arsenic exposure in rat lungs. Tissue changes, inflammation, autophagy, and other physiological responses were observed in this study. Results showed that low‐concentration exposure of arsenite through water intake could initiate autophagy and inflammation in lungs but high concentration exposure produced a weak autophagy response and accentuated inflammation with the possibility of a chronic inflammation environment emerging followed by tumorigenesis.