Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes.
Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes.
复制标题
胱抑素超家族。
DOI：
--
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Nobuyo Maeda
中科院分区：
文献类型：
--
作者：
Eiichi Saitoh;S. Isemura;Kazuo Sanada;Kim Hs;O. Smithies;Nobuyo Maeda
人唾液中至少含有三种半胱氨酸蛋白酶抑制剂（胱抑素S、胱抑素SN和胱抑素SA），它们具有相似但不同的氨基酸序列。胱抑素SN的CST 1基因和胱抑素SA的CST 2基因的核苷酸序列彼此高度同源，并与胱抑素C cDNA的相应区域和胱抑素C基因的EcoRI-PstI片段高度同源。激肽原基因中的三个半胱抑素样结构域和唾液半胱抑素基因共享相同的基因组织。这些数据表明II家族胱抑素基因与III家族胱抑素基因在进化上是相关的。
Human saliva contains at least three molecular species of cystatin S-type cysteine proteinase inhibitor (cystatin S, cystatin SN and cystatin SA), which have similar but distinct amino-acid sequences. The nucleotide sequences of the CST 1 gene for cystatin SN and the CST 2 gene for cystatin SA are highly homologous to each other and to the corresponding regions of the cDNA for cystatin C and the EcoRI-PstI fragment from the cystatin C gene. Three cystatin-like domains in the kininogen gene and the salivary cystatin genes share the same gene organizations. These data demonstrate that family II cystatin genes are evolutionarily related to family III cystatin genes.