[The natural history of serous retinal pigment epithelial detachment].
[The natural history of serous retinal pigment epithelial detachment].
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浆液性视网膜色素上皮脱离的自然史。
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
A. Shirakashi
中科院分区：
文献类型：
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作者：
A. Shirakashi
回顾性研究 21 名血管弓内浆液性视网膜色素上皮脱离 (PED) 患者的 25 只眼睛的自然史，以阐明 PED 发展为脉络膜新生血管膜 (NVM) 的危险因素（平均年龄 55.8 +/- 10.4 岁；平均随访时间 18.8 +/- 10.3 个月）。在随访期间，6只眼（24%）出现NVM。首次就诊时发生 NVM 的重要危险因素包括：患者年龄较大（大于 60 岁）：PED 尺寸较大（大于椎间盘直径 1 倍）：中央凹中存在 PED。感觉性视网膜脱离的眼睛在随访期间没有减少，发生 NVM 的风险显着较高。与没有发生 NVM 的眼睛相比，发生 NVM 的眼睛的视力预后明显较差。生命表分析（Kaplan-Meier 法）显示，3 个月时发生 NVM 的发生率为 8%，6 个月时为 16%，9 个月时为 24%。这些结果表明，除了患者年龄之外，PED的大小和位置以及感觉性视网膜脱离的临床病程可能是PED预后的重要决定因素。
The natural history of 25 eyes of 21 patients with serous retinal pigment epithelial detachment (PED) within the vascular arcade was retrospectively studied to clarify the risk factors for development of choroidal neovascular membranes (NVM) from PED (mean age 55.8 +/- 10.4 years; mean follow-up 18.8 +/- 10.3 months). During the follow-up period, 6 eyes (24%) developed NVM. The significant risk factors for NVM development at the first visit were: older patient age (greater than 60 years): larger PED size (greater than 1 disc diameter): presence of PED in the fovea. Eyes with sensory retinal detachment that did not decrease during the follow-up had a significant high risk for NVM development. Eyes with NVM development showed significantly worse visual prognosis as compared to those with no NVM development. Life-table analysis (Kaplan-Meier method) showed that the incidence of developing NVM was 8% at 3 months, 16% at 6 months, and 24% at 9 months. These results suggested that the size and location of PED and clinical course of sensory retinal detachment in addition to the patient age may be important determinants of the prognosis of PED.