Effects of naturally occurring G103D point mutation of AQP5 on its water permeability, trafficking and cellular localization in the submandibular gland of rats
Effects of naturally occurring G103D point mutation of AQP5 on its water permeability, trafficking and cellular localization in the submandibular gland of rats
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DOI：
10.1042/bc20100086
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发表时间：
2011-02
影响因子：
2.7
通讯作者：
M. Karabasil;T. Hasegawa;A. Azlina;N. Purwanti;C. Yao;T. Akamatsu;S. Tomioka;K. Hosoi
中科院分区：
文献类型：
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作者：
M. Karabasil;T. Hasegawa;A. Azlina;N. Purwanti;C. Yao;T. Akamatsu;S. Tomioka;K. Hosoi
背景资料。水通道蛋白（AQP）是一种水通道蛋白，几乎在所有生物中都有表达。迄今为止，已确定了13个AQP成员（AQP 0 -12）。已知AQP 5主要在外分泌细胞中表达，包括唾液腺腺泡细胞。在大鼠AQP 5基因中较早发现了天然存在的点突变（G308 A，Gly 103> Asp 103）[Murdiastuti，Purwanti，Karabasil，Li，Yao，Akamatsu，Kanamori和Hoclane（2006）Am. J. Physiol.291，G1081-G1088];在该突变体中，在刺激和未刺激条件下的初始唾液分泌速率低于野生型动物。
Background information. AQPs (aquaporins) are water channel proteins that are expressed in almost all living things. In mammalians, 13 members of AQPs (AQP0–12) have been identified so far. AQP5 is known to be expressed mostly in the exocrine cells, including the salivary gland acinar cells. A naturally occurring point mutation (G308A, Gly103 > Asp103) was earlier found in the rat AQP5 gene [Murdiastuti, Purwanti, Karabasil, Li, Yao, Akamatsu, Kanamori and Hosoi (2006) Am. J. Physiol. 291, G1081–G1088]; in this mutant, the rate of initial saliva secretion under stimulated and unstimulated conditions is less than that for the wt (wild‐type) animals.