Diabetic microvascular complications - can the presence of one predict the development of another?
Diabetic microvascular complications - can the presence of one predict the development of another?
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DOI：
10.1016/j.jdiacomp.2006.03.001
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发表时间：
2006-07-01
影响因子：
3
通讯作者：
Vignati, Louis
中科院分区：
文献类型：
--
作者：
Girach, Aniz;Vignati, Louis
全世界糖尿病患者的数量正在急剧增加。儿童和青少年肥胖的流行率上升也与这些年轻年龄组中2型糖尿病确诊病例数量的惊人增长有关。尽管采用了治疗策略，但糖尿病仍然是新发失明、终末期肾病和下肢截肢的主要原因，所有这些都是糖尿病患者发病率和死亡率过高的原因。此外，糖尿病相关并发症的管理产生了巨大的成本。为了及时给予治疗，早期发现有糖尿病微血管并发症风险的患者是至关重要的。糖尿病病程、血糖、血压和脂质控制一直被证明与糖尿病视网膜病变、神经病变和肾病相关，但迄今为止，一种糖尿病微血管并发症与另一种糖尿病微血管并发症的关系尚未得到明确描述。对文献的回顾提出了一个问题，除了其他已知的危险因素外，糖尿病微血管并发症本身可能存在关系，这似乎比稀疏的已发表数据所表明的要强得多。一个能够预测糖尿病微血管并发症发展的评分系统，可能有助于早期识别高危患者，从而对患者的生活质量产生积极影响，减轻糖尿病及其并发症的经济负担。(c) 2006爱思唯尔公司版权所有。
The number of people with diabetes is increasing dramatically worldwide. The rising prevalence of obesity in childhood and adolescence has also been linked to a startling increase in the number of diagnosed cases of type 2 diabetes in these younger age groups. Despite the introduction of treatment strategies, diabetes remains a major cause of new-onset blindness, end-stage renal disease, and lower leg amputation, all of which contribute to the excess morbidity and mortality in people with diabetes. Furthermore, the management of diabetes-related complications generates substantial costs. In order that timely treatment can be given, it is essential that patients at risk for the development of diabetic microvascular complications are identified earlier. Diabetes duration and glycemic, blood pressure, and lipid control have consistently been shown to correlate with diabetic retinopathy, neuropathy, and nephropathy, but to date, the relationship of one diabetic microvascular complication to another has not been clearly described. A review of the literature has raised the question that apart from other known risk factors, there is a possible relationship among the diabetic microvascular complications themselves, and this appears to be much stronger than the sparse published data on it would suggest. A scoring system that can predict the development of diabetic microvascular complications may facilitate the early identification of those patients at risk and, consequently, have a positive impact on patients' quality of life and reduce the economic burden of diabetes and its complications. (c) 2006 Elsevier Inc. All rights reserved.