Effect of evacuation on liver function after the Fukushima Daiichi Nuclear Power Plant accident: The Fukushima Health Management Survey.
Effect of evacuation on liver function after the Fukushima Daiichi Nuclear Power Plant accident: The Fukushima Health Management Survey.
复制标题
DOI：
10.1016/j.je.2016.05.006
复制
发表时间：
2017-04
影响因子：
4.7
通讯作者：
Fukushima Health Management Survey Group
中科院分区：
文献类型：
--
作者：
Takahashi A;Ohira T;Hosoya M;Yasumura S;Nagai M;Ohira H;Hashimoto S;Satoh H;Sakai A;Ohtsuru A;Kawasaki Y;Suzuki H;Kobashi G;Ozasa K;Yamashita S;Kamiya K;Abe M;Fukushima Health Management Survey Group
东日本大地震和随后的福岛第一核电站事故导致居民从正常生活转向以疏散为重点的生活。我们评估了这场灾难前后的肝功能，以阐明疏散对肝功能的影响。这项研究是对居住在福岛第一核电站附近的26,006名日本男性和女性进行的纵向调查。这项研究是利用2008年至2010年期间对40-90岁的人进行的年度健康检查数据进行的。2011年6月至2013年3月底进行随访检查，平均随访1.6年。比较了疏散人员和非疏散人员在灾难前后肝功能的变化。我们还根据饮酒状况对各组进行了评估。所有参与者的肝功能障碍患病率从灾难前的16.4%显著增加到灾难后的19.2%。肝功能不全的发生率显着高于撤离人员比非撤离人员。多因素Logistic回归分析显示，疏散与居民肝功能损害显著相关。这是第一项研究表明，福岛第一核电站灾难导致的疏散与肝功能障碍的增加有关。东日本大地震后，肝功能障碍的患病率增加。肝功能障碍患病率的变化在撤离人员中最大。排空是与肝功能障碍相关的一个危险因素。
The Great East Japan Earthquake and subsequent Fukushima Daiichi Nuclear Power Plant accident caused residents to switch from their normal lives to lives focused on evacuation. We evaluated liver function before and after this disaster to elucidate the effects of evacuation on liver function. This study was a longitudinal survey of 26,006 Japanese men and women living near the Fukushima Daiichi Nuclear Power Plant. This study was undertaken using data from annual health checkups conducted for persons aged 40–90 years between 2008 and 2010. Follow-up examinations were conducted from June 2011 to the end of March 2013, with a mean follow up of 1.6 years. Changes in liver function before and after the disaster were compared among evacuees and non-evacuees. We also assessed groups according to alcohol drinking status. The prevalence of liver dysfunction significantly increased in all participants from 16.4% before to 19.2% after the disaster. The incidence of liver dysfunction was significantly higher in evacuees than in non-evacuees. Multivariate logistic regression analysis showed that evacuation was significantly associated with liver dysfunction among residents. This is the first study to show that evacuation due to the Fukushima Daiichi nuclear power plant disaster was associated with an increase in liver dysfunction. Prevalence of liver dysfunction increased after the Great East Japan Earthquake. The change in prevalence of liver dysfunction was greatest in evacuees. Evacuation is one risk factor associated with liver dysfunction.