Ocular findings in two colonies of gray mouse lemurs (Microcebus murinus)
Ocular findings in two colonies of gray mouse lemurs (Microcebus murinus)
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DOI：
10.1111/j.1463-5224.2007.00491.x
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发表时间：
2007-01-01
影响因子：
1.6
通讯作者：
Chahory, Sabine
中科院分区：
文献类型：
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作者：
Beltran, William A.;Vanore, Maria;Chahory, Sabine
目的研究两群灰狐猴白内障及其他眼部病变的发病率和特征。所有个体均为国家自然历史博物馆（法国）的财产，并被安置在巴黎（菌落#1：75只动物检查）或Brunoy（菌落#2：143只动物）。方法对所有动物在瞳孔扩张前后进行眼部检查，包括裂隙灯生物显微镜检查和间接检眼镜检查。在这两个群体中，有限数量的个体在初始眼部检查后数月至2年之间进行了重新检查。在此期间死亡的初期或不成熟的白内障，5只小鼠狐猴的眼睛被收集，并处理为常规的组织病理学examination.Results白内障的发病率很高，观察到在两个殖民地（48%的殖民地#1; 21%的殖民地#2）。白内障主要是双侧的，开始于前和/或后囊下区域，并且似乎是缓慢进展的。观察到透镜浑浊的最早年龄为3.5岁，超过50%的7岁以上鼠狐猴被诊断出患有白内障。完全性白内障导致失明，偶尔与其他眼部lesions.Conclusion，我们报告了一个高发病率的收购，缓慢进行，双边白内障在两个殖民地的小鼠狐猴（Microcebus murinus）。需要进行进一步的研究，以确定这种疾病在这个物种的原因。
Objective To determine the incidence and describe the characteristics of cataracts and other ocular lesions found in two colonies of gray mouse lemurs (Microcebus murinus).Animals studied A total number of 218 mouse lemurs (age range: 4 months-11 years) were included in this study. All individuals were property of the Museum National d'Histoire Naturelle (France), and were housed either in Paris (colony #1: 75 animals examined), or in Brunoy (colony #2: 143 animals).Methods Ocular examinations were performed on all animals before and after pupil dilation, and included slit-lamp biomicroscopy and indirect ophthalmoscopy. In both colonies, a limited number of individuals were re-examined between several months and 2 years following the initial eye examinations. The eyes of five mouse lemurs with incipient or immature cataracts that died during this period were collected, and processed for routine histopathologic examination.Results A high incidence of cataracts was observed in both colonies (48% in colony #1; 21% in colony #2). Cataracts were predominantly bilateral, started in the anterior and/or posterior subcapsular area, and appeared to be slowly progressive. The earliest age at which lens opacities were observed was 3.5 years, and more than 50% of mouse lemurs over 7 years of age were diagnosed with cataracts. Complete cataracts led to blindness and were occasionally associated with other ocular lesions.Conclusion We report a high incidence of acquired, slowly progressive, bilateral cataracts in two colonies of mouse lemurs (Microcebus murinus). Further studies need to be conducted to determine the cause of this disease in this species.