The nucleoside uridine isolated in the gas phase.
The nucleoside uridine isolated in the gas phase.
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在气相中分离的核苷尿苷。
DOI：
10.1002/anie.201412460
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发表时间：
2015-03-02
期刊：
影响因子：
--
通讯作者：
Alonso JL
中科院分区：
文献类型：
--
作者：
Peña I;Cabezas C;Alonso JL
在这里，我们提出了首次实验观察分离的核苷尿苷，放置在气相中的激光消融和傅立叶变换微波技术表征。不受自然环境的整体影响，反/C2‘-Endo-g+构象被认为是尿苷最稳定的形式。含有尿嘧啶和核糖的分子内氢键在核苷的稳定中起着重要的作用。
Herein we present the first experimental observation of the isolated nucleoside uridine, placed in the gas phase by laser ablation and characterized by Fourier transform microwave techniques. Free from the bulk effects of their native environments, anti/C2’-endo-g+ conformation has been revealed as the most stable form of uridine. Intramolecular hydrogen bonds involving uracil and ribose moieties have been found to play an important role in the stabilization of the nucleoside.