Photocrosslinking characteristics and mechanical properties of diethyl fumarate/poly(propylene fumarate) biomaterials
Photocrosslinking characteristics and mechanical properties of diethyl fumarate/poly(propylene fumarate) biomaterials
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DOI：
10.1016/s0142-9612(02)00178-3
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发表时间：
2002-11-01
期刊：
影响因子：
14
通讯作者：
Mikos, AG
中科院分区：
文献类型：
--
作者：
Fisher, JP;Dean, D;Mikos, AG
组织工程材料的发展将为目前临床使用的自体移植物、同种异体移植物、不可降解聚合物、陶瓷和金属提供有吸引力的替代品。为此，聚富马酸丙烯（PPF），一种由富马酸二乙酯（DEF）合成的粘性聚酯，已被研究用于工程骨移植物。我们利用光引发剂（2,4,6-三甲基苯甲酰）苯基氧化膦（BAPO）和低水平的紫外线照射，研究了溶解在其前驱体DEF中的PPF的光交联。采用2 × 2 × 4的三因子设计，研究了PPF数、平均分子量、BAPO引发剂含量和DEF含量对光交联性能和力学性能的影响。当DEF含量从0%增加到75%时，未固化DEF/PPF溶液的粘度下降了3个数量级以上。放热光交联反应释放的热量很低，测试的任何配方释放的热量不超过160 J/g。结果表明，所有样品的最大光交联温度均保持在47℃以下。随着DEF含量的增加，溶质分数和溶胀度普遍增加。压缩力学性能在小梁骨范围内，最强试样弹性模量为195.3 +/- 17.5 MPa，断裂强度为68.8 +/- 9.4 MPa。最后，研究结果表明，低DEF前驱体浓度有利于PPF交联，高DEF前驱体浓度阻碍PPF交联。这些新型的DEF/PPF溶液可能比纯PPF溶液更适合作为工程骨移植物的基础，因为它们(1)具有较低的粘度，因此易于处理；(2)在骨折处形成具有抗压强度的聚合物网络，适合用于骨小梁置换；(3)可以很容易地制成具有多种结构的固体。(C) 2002 Elsevier Science Ltd.版权所有。
The development of tissue engineered materials for the treatment of large bone defects would provide attractive alternatives to the autografts, allografts, non-degradable polymers, ceramics, and metals that are currently used in clinical settings. To this end, poly(propylene fumarate) (PPF), a viscous polyester synthesized from diethyl fumarate (DEF), has been studied for use as an engineered bone graft. We have investigated the photocrosslinking of PPF dissolved in its precursor, DEF, using the photoinitiator bis(2,4,6-trimethylbenzoyl) phenylphosphine oxide (BAPO) and low levels of ultraviolet light exposure. A three factor, 2 x 2 x 4 factorial design was developed, studying the effects of PPF number average molecular weight, BAPO initiator content, and DEF content upon photocrosslinking characteristics and mechanical properties. Uncured DEF/PPF solution viscosity fell over three orders of magnitude as DEF content was increased from 0% to 75%. The exothermic photocrosslinking reaction released low levels of heat, with no more than 160 J/g released from any formulation tested. As a result, the maximum photocrosslinking temperature remained below 47degreesC for all samples. Both sol fraction and swelling degree generally increased with increasing DEF content. Compressive mechanical properties were within the range of trabecular bone, with the strongest samples possessing an elastic modulus of 195.3 +/- 17.5 MPa and a fracture strength of 68.8 +/- 9.4 MPa. Finally, the results indicate that PPF crosslinking was facilitated at low DEF precursor concentrations, but hindered at higher precursor concentrations. These novel DEF/PPF solutions may be preferred over pure PPF as the basis for an engineered bone graft because they (1) exhibit reduced viscosity and thus are easily handled, (2) form polymer networks with compressive strength at fracture suitable for consideration for trabecular bone replacement, and (3) may be readily fabricated into solids with a wide range of structures. (C) 2002 Elsevier Science Ltd. All rights reserved.