Sustained virological response based on rapid virological response in genotype-3 chronic hepatitis C treated with standard interferon in the Pakistani population
Sustained virological response based on rapid virological response in genotype-3 chronic hepatitis C treated with standard interferon in the Pakistani population
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DOI：
10.3748/wjg.14.2218
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发表时间：
2008-04-14
影响因子：
4.3
通讯作者：
Afsar, Salahuddin
中科院分区：
文献类型：
--
作者：
Zuberi, Bader Faiyaz;Zuberi, Faisal Faiyaz;Afsar, Salahuddin
目的：记录持续病毒学应答（SVR）的快速病毒学应答（RVR）的基因型-3慢性丙型肝炎与标准干扰素（SdIF）。方法：丙型肝炎基因型-3患者在2006年7月至2007年6月期间。进行全血细胞计数、凝血酶原时间、ALT、白蛋白、HCV RNA定性。用SdIF和利巴韦林治疗4 wk，重复HCV RNA定性。检测呈阴性的人被分配到A组，其余人被分配到B组。A、B组分别治疗16、24 wk。治疗24 wk后复查HCV RNA。通过卡方检验比较最终病毒学应答和持续病毒学应答。结果：治疗16 wk后RCV RNA检测阴性34例（45.9%），阳性40例（54.1%），分别分为A、B组。A组和B组的SVR分别为58.8%和27.8%。发生RVR的患者的SVR率显著高于未发生RVR的患者（P = 0.0; γ = 2）。两组合并ETR和SVR分别为70%和33%。ROC曲线的治疗前年龄，ALT和白蛋白的SVR显示只有ALT有一个显着的大面积的曲线下面积。结论：SVR率较高的患者谁有RVR与SdIF和高治疗前ALT值相关的概率RVR。(C)2008年WJG。All rights reserved.
AIM: To document the sustained virological response (SVR) in rapid virological responders (RVR) of genotype-3 chronic hepatitis C with standard interferon (SdIF).METHODS: Hepatitis C genotype-3 patients during the period July 2006 and June 2007 were included. Complete blood counts, prothrombin time, ALT, albumin, qualitative HCV RNA were done. SdIF and ribavirin were given for 4 wk and qualitative HCV RNA was repeated. Those testing negative were allocated to group-A while the rest were allocated to group-B. Treatment was continued a total of 16 and 24 wk for group A and B respectively. HCV RNA was repeated after 24 wk of treatment. End virological and sustained virological responses were compared by chi(2) test. ROC of pretreatment age, ALT and albumin were plotted for failure to achieve SVR.RESULTS: Of 74 patients treated, RCV RNA after 16 wk of therapy became undetectable in 34 (45.9%) and was detectable in 40 (54.1%) and were allocated to groups A and B respectively. SVR was achieved in 58.8% and 27.8% in groups A and B respectively. SVR rates were significantly higher in patients who had RVR as compared to those who did not (P = 0.0; gamma = 2). Both groups combined ETR and SVR were 70% and 33% respectively. ROC plots of pretreatment age, ALT and albumin for SVR showed only ALT to have a significantly large area under the curve.CONCLUSION: SVR rates were higher in patients who had RVR with SdIF and high pre treatment ALT values correlated to probability of having RVR. (C) 2008 WJG. All rights reserved.