Gross Persistence of Capillary Plasma Perfusion after Middle Cerebral Artery Occlusion in the Rat Brain
Gross Persistence of Capillary Plasma Perfusion after Middle Cerebral Artery Occlusion in the Rat Brain
复制标题
大鼠大脑中大脑动脉闭塞后毛细血管血浆灌注的总体持续性
DOI：
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发表时间：
1994
影响因子：
6.3
通讯作者：
W. Kuschinsky
中科院分区：
文献类型：
--
作者：
H. Theilen;H. Schröck;W. Kuschinsky
大脑中动脉（MCA）颞下闭塞后，测量大鼠大脑不同皮质区域的灌注和现有毛细血管的密度。一组大鼠的 MCA 闭塞后立即验证毛细血管灌注模式（灌注毛细血管与非灌注毛细血管），第二组则在 1 小时后使用相同脑切片中毛细血管形态和血浆灌注的荧光双重染色进行验证。此外，在MCA闭塞后1小时，使用放射自显影碘-[14C]-安替比林法测量另一组大鼠的局部脑血流量(CBF)。尽管MCA闭塞后1小时皮质CBF下降高达75%，但大多数毛细血管中血浆灌注并未完全停止（伊文思蓝循环时间为10秒）。除表现出更广泛的毛细血管灌注缺乏的大脑外，所有大脑中 MCA 闭塞后立即和 1 小时后的毛细血管中仅检测到小片状灌注不足（脑切片 <0.1 mm2）。数据显示，MCA 闭塞后皮质 CBF 急剧减少，但并未伴随相应数量的非灌注毛细血管。
The densities of perfused and existing capillaries were measured in different cortical regions of rat brains after subtemporal occlusion of the middle cerebral artery (MCA). Capillary perfusion patterns (perfused capillaries versus nonperfused capillaries) were verified immediately after MCA occlusion in one group of rats and 1 h later in a second group using fluorescent double staining of capillary morphology and plasma perfusion in identical brain sections. In addition, local cerebral blood flow (CBF) was measured in another group of rats 1 h after MCA occlusion using the autoradiographic iodo-[14C]-antipyrine method. Although cortical CBF was decreased by up to 75% 1 h after MCA occlusion, plasma perfusion was not completely stopped in most capillaries (circulation time of Evans blue, 10 s). Only small patchy perfusion deficits (<0.1 mm2 of brain section) were detected in the capillaries immediately and 1 h after MCA occlusion in all brains except for one that exhibited a more extensive lack of capillary perfusion. The data show that a drastic reduction of cortical CBF after MCA occlusion is not accompanied by a corresponding amount of nonperfused capillaries.
白蛋白和红细胞流经脑微血管的差异和相似之处。
DOI：
10.1152/ajpheart.1992.262.5.h1515
发表时间：
1992
期刊：
The American journal of physiology
影响因子：
--
作者：
Tajima,A;Nakata,H;Lin,SZ;Acuff,V;Fenstermacher,J
通讯作者：
Fenstermacher,J