Responses of red nucleus neurons to antidromic and synaptic activation.
Responses of red nucleus neurons to antidromic and synaptic activation.
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红核神经元对逆向和突触激活的反应。
DOI：
10.1152/jn.1975.38.4.947
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发表时间：
1975
影响因子：
2.5
通讯作者：
H. Táboříková
中科院分区：
文献类型：
--
作者：
J. Eccles;P. Scheid;H. Táboříková
描述了432个轴突沿脊髓向下投射的红核（RN）神经元的反应。几乎一半是在最初的一系列18个实验麻醉猫，其余的是在第二系列12个实验去大脑未麻醉猫。两个系列之间的差异不大。所有记录均来自单个神经元，使用细胞外玻璃微电极，该电极插入右侧上级丘并以标准方向指向右侧红核。RN神经元的识别通过位置、随后的组织学检查以及脊髓的逆行侵袭来进行。将脊髓刺激电极放置在C2和L2节段水平的左侧红核脊髓束附近。轴突传导速度由L2和C2逆向反应之间的潜伏期差异计算，通常在60-130 m/s的范围内，位于红核的所有神经元中有97%的轴突投射到C2水平，37%投射到L2水平。刺激对侧（左）间位核，观察229个RN神经元的反应。在10个（5%）有逆向反应interpositus和C2刺激，发现在解剖学描述的罕见的轴突侧支从红核脊髓纤维interpositus核。209例（91%）有明显的单突触兴奋。冲动产生的潜伏期通常为1.0-1.8 ms，其模态值为1.4 ms。RN神经元的传入输入由刺激四肢的主要皮肤神经或刺激对侧前肢和后肢的皮肤机械感受器提供。
An account is given of the responses of 432 red nucleus (RN) neurons with axons projecting down the spinal cord. Almost half were in an initial series of 18 experiments on anesthetized cats, and the remainder were in a second series of 12 experiments on decerebrate unanesthetized cats. The differences between the two series were of little significance. All recording was from single neurons using extracellular glass microelectrodes that were inserted throught the right superior colliculus and directed to the right red nucleus at a standard orientation. Identification of RN neurons was both by location, checked by subsequent histology, and by antidromic invasion from the spinal cord. The spinal stimulating electrodes were placed in proximity to the left rubrospinal tract at C2 and L2 segmental levels. Axonal conduction velocities were calculated from the latency differential between the L2 and C2 antidromic responses and were usually in the range 60-130 m/s, 97% of all neurons located in the red nucleus had axons projecting to the C2 level, and 37% projected to the L2 level. The responses of 229 RN neurons were observed with stimulation applied to the contralateral (left) interpositus nucleus. In 10 (5%) there were antidromic responses to both interpositus and C2 stimulation, a finding in good agreement with the anatomical description of rare axon collaterals from rubrospinal fibers to the interpositus nucleus. In 209 (91%), there was a clear monosynaptic excitation. The impulse generation was at a latency usually of 1.0-1.8 ms, which a modal value of 1.4 ms. The afferent inputs to RN neurons were provided by stimulation either of predominantly cutaneous nerves in all four limbs or of cutaneous mechanoreceptors of the contralateral forelimb and hindlimb...