Four-fold Channel-Nicked Human Ferritin Nanocages for Active Drug Loading and pH-Responsive Drug Release
Four-fold Channel-Nicked Human Ferritin Nanocages for Active Drug Loading and pH-Responsive Drug Release
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DOI：
10.1002/anie.201800516
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发表时间：
2018-03-05
影响因子：
16.6
通讯作者：
Jung, Yongwon
中科院分区：
文献类型：
--
作者：
Ahn, Byungjun;Lee, Seong-Gyu;Jung, Yongwon
人铁蛋白由于其固有的或可获得的对癌细胞的靶向能力和用于药物负载的中空笼结构而成为基于无毒蛋白质的药物递送的新兴平台。然而，仍然缺乏可靠的策略，高水平的药物包封在铁蛋白腔和迅速的细胞药物释放。铁蛋白纳米笼的开发具有部分开放的疏水性通道，为Fel II缀合药物的自发和高度累积装载以及在内质pH下pH响应性快速药物释放提供了稳定的途径。多种癌症相关化合物，例如阿霉素、姜黄素和槲皮素，被主动且大量地装载到制备的有切口的铁蛋白上。这些最小修饰的铁蛋白上的药物以高毒性有效地递送到癌细胞内。
Human ferritins are emerging platforms for nontoxic protein-based drug delivery, owing to their intrinsic or acquirable targeting abilities to cancer cells and hollow cage structures for drug loading. However, reliable strategies for high-level drug encapsulation within ferritin cavities and prompt cellular drug release are still lacking. Ferritin nano-cages were developed with partially opened hydrophobic channels, which provide stable routes for spontaneous and highly accumulated loading of FeII-conjugated drugs as well as pH-responsive rapid drug release at endoplasmic pH. Multiple cancer-related compounds, such as doxorubicin, curcumin, and quercetin, were actively and heavily loaded onto the prepared nicked ferritin. Drugs on these minimally modified ferritins were effectively delivered inside cancer cells with high toxicity.