Vitellogenin is an immunocompetent molecule for mother and offspring in fish
Vitellogenin is an immunocompetent molecule for mother and offspring in fish
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卵黄蛋白原是鱼类母亲和后代的免疫活性分子
DOI：
10.1016/j.fsi.2015.08.011
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发表时间：
2015
影响因子：
4.7
通讯作者：
Cui Pengfei
中科院分区：
文献类型：
--
作者：
Zhang Shicui;Dong Yuan;Cui Pengfei
在过去的十年中，我们对卵黄蛋白原（Vg）在生殖中的功能的理解经历了一个转变，同时对Vg在免疫中的作用有了新的认识。最初，Vg被认为是雌性特有的生殖蛋白，其被切割成卵黄蛋白如卵黄脂蛋白（Pv）和卵黄脂磷蛋白（Lv），储存在卵中，为胚胎发育提供营养。近年来，研究表明Vg是一种免疫相关分子，参与宿主对细菌和病毒等微生物的防御。此外，Pv和Lv都是Vg的蛋白水解裂解产物，在胚胎发育中起防御作用。重要的是，卵黄蛋白衍生的小肽也显示出抗微生物活性。这些数据共同表明，Vg除了参与卵黄蛋白形成外，还通过在亲鱼及其后代中作为免疫相关分子发挥非生殖作用。这也表明卵黄蛋白及其降解肽是母体免疫的新参与者，为研究生殖蛋白的功能开辟了新途径。
Our understanding of the function of vitellogenin (Vg) in reproduction has undergone a transformation over the past decade in parallel with new insights into the role of Vg in immunity. Initially, Vg was regarded as a female-specific reproductive protein, which is cleaved into yolk proteins such as phosvitin (Pv) and lipovitellin (Lv), stored in egg, providing the nutrients for developing embryos. Recently, Vg is shown to be an immune-relevant molecule involved in the defense of the host against the microbes including bacterium and virus. Furthermore, Pv and Lv, that both are proteolytically cleaved products of Vg, play a defense role in developing embryos. Importantly, yolk protein-derived small peptides also display antimicrobial activity. These data together indicate that Vg, in addition to being involved in yolk protein formation, plays a non-reproductive role via functioning as an immune-relevant molecule in both parent fishes and their offspring. It also shows that yolk proteins and their degraded peptides are novel players in maternal immunity, opening a new avenue to study the functions of reproductive proteins.