Association found between the promoter region polymorphism in the apolipoprotein A-V gene and the serum triglyceride level in Japanese schoolchildren
Association found between the promoter region polymorphism in the apolipoprotein A-V gene and the serum triglyceride level in Japanese schoolchildren
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DOI：
10.1007/s00439-002-0825-0
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发表时间：
2002-12-01
期刊：
影响因子：
5.3
通讯作者：
Tomura, S
中科院分区：
文献类型：
--
作者：
Endo, K;Yanagi, H;Tomura, S
本研究的目的是评估载脂蛋白AN （APOA5）基因单核苷酸多态性3 （SNP3）对日本学童血清甘油三酯（TG）水平的影响。确定基因型的频率。我们分析了552名学童。APOA5基因T/T、T/C和C/C基因型频率分别为225个（40.8%）、263个（47.6%）和64个（11.6%）。经年龄、性别和肥胖指数调整后，基因型组间血清TG水平差异有统计学意义(T/T 71.6+/-34.8 mg/dl, T/C 80.7+/-36.1 mg/dl, C/C 94.4+/-69.4 mg/dl， P
The purpose of this study was to assess the influence of single nucleotide polymorphism 3 (SNP3) of the apolipoprotein AN (APOA5) gene on the serum triglyceride (TG) level in Japanese schoolchildren. To determine the frequency of the genotype. we analyzed 552 schoolchildren. The frequencies of the T/T, T/C and C/C genotypes of the APOA5 gene were 225 (40.8%), 263 (47.6%) and 64 (11.6%), respectively. The serum TG level was significantly different among the genotypic groups after adjustments for age, gender and obesity index (T/T 71.6+/-34.8 mg/dl, T/C 80.7+/-36.1 mg/dl, C/C 94.4+/-69.4 mg/dl, P