Autonomic responses to physiological stressors in women with type 2 diabetes
Autonomic responses to physiological stressors in women with type 2 diabetes
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DOI：
10.1007/s10286-008-0461-4
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发表时间：
2008-04-01
影响因子：
5.8
通讯作者：
Kanaley, Jill A.
中科院分区：
文献类型：
--
作者：
Franklin, Ruth M.;Baynard, Tracy;Kanaley, Jill A.
目的比较2型糖尿病合并肥胖和非肥胖女性在空腹和糖负荷后握力（HG）和冷加压（CP）时的自主神经功能15名无2型糖尿病的肥胖妇女（48 +/-2岁）和12名非肥胖妇女（49 +/-2岁）参加了这项研究。心率变异性（HRV）在自主神经功能测试中测定，在空腹状态和葡萄糖激发后进行结果患有和不患有糖尿病的肥胖妇女和非肥胖妇女在禁食和葡萄糖激发后的反应相似，使得在禁食状态下低频功率（LF（nu））标准化为总功率（TP），对数转换后的低频高频比（LnLF/HF）和心率（HR）随自主神经功能任务的进行而显著增加（P < 0.05），而HF（nu）随自主神经功能任务的进行而显著降低（P < 0.05）。空腹状态下，握柄组LnTP较CP组低，HR较CP组高（P < 0.05）。在葡萄糖负荷状态下，LF（nu）、LnLF/HF和HR增加（P < 0.05），HF（nu）显著降低（P < 0.05）。自主神经功能测试结果在肥胖妇女、糖尿病妇女和非肥胖妇女之间无差异。HG测试引起了更大的降低HRV总功率相比，CP。这表明，HG可能是更有用的，当检查复杂的糖尿病妇女的自主神经功能。
Objective To compare autonomic function, measured during handgrip (HG) and cold pressor (CP), between obese with and without type 2 diabetes and non-obese women in fasting and post-glucose load states.Methods Twelve obese women with type 2 diabetes (50 +/- 1 years), 15 obese women without type 2 diabetes (48 +/- 2 years), and 12 non-obese women (49 +/- 2 years) participated in this study. Heart rate variability (HRV) was determined during autonomic function tests, conducted in both the fasting state and after a glucose challenge (oral glucose tolerance test-OGTT).Results Obese women with and without diabetes and non-obese women responded similarly fasted and post-glucose challenge, such that in the fasted state low frequency power normalized (LF(nu)) to total power (TP), log transformed (Ln) low frequency to high frequency ratio (LnLF/HF) and heart rate (HR) significantly increased with the autonomic functional tasks (P < 0.05), whereas HF(nu) significantly decreased with the tasks (P < 0.05). Handgrip elicited a lower LnTP and a higher HR (P < 0.05) when compared to CP in the fasted state. In the glucose challenged state LF(nu), LnLF/HF and HR increased (P < 0.05) and HF(nu) significantly decreased (P < 0.05).Interpretation Results of autonomic testing did not differ between obese women, with and without diabetes, and non-obese women. The HG test elicited a greater reduction in HRV total power compared to the CP. This suggests that HG may be more useful when examining autonomic function in women with complicated diabetes.