The extent of alveolar bone loss is associated with impaired glucose tolerance in Japanese men
The extent of alveolar bone loss is associated with impaired glucose tolerance in Japanese men
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DOI：
10.1902/jop.2006.050061
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发表时间：
2006-03-01
影响因子：
4.3
通讯作者：
Yamashita, Y.
中科院分区：
文献类型：
--
作者：
Saito, T.;Murakami, M.;Yamashita, Y.
背景：据报道，牙周病的治疗对糖尿病患者的血糖控制有有益的影响。最近的一项研究表明，在使用口服葡萄糖耐量试验（OGTT）的非糖尿病患者中，财力雄厚与过去葡萄糖耐受不良的发展显著相关。这些发现表明牙周病是糖尿病的一个危险因素，尽管还需要更多的证据。方法：对193名年龄在50 ~ 54岁之间、至少有10颗牙齿的日本男性在日本自卫队退役前进行了全面的健康检查。用x线全景片测量后牙牙槽骨丢失情况。给予OGTT，并确定糖耐量受损（IGT）和糖尿病。在调整已知的糖尿病危险因素后，分析了牙槽骨损失与牙根长度的平均比率与OGTT结果之间的关系。结果：在牙槽骨丢失数较高的人群中，IGT患者的比例明显增加（P < 0.05）。在排除糖尿病受试者的多因素logistic回归分析中，牙槽骨丢失分位数越高，IGT与正常糖耐量（NGT）的调整OR值越高（趋势P = 0.03）。在牙槽骨丢失比例最高的受试者中，IGT与NGT的调整OR为4.27(95%可信区间[0]:1.41 ~ 12.9；P = 0.01)。结论：牙槽骨丢失程度与IGT显著相关，提示牙周炎伴牙槽骨丢失与糖耐量降低相关。
Background: The treatment of periodontal disease in diabetic patients is reported to have a beneficial effect on their glucose control. A recent study indicated that having deep pockets is significantly associated with past development of glucose intolerance in non-diabetic individuals using an oral glucose tolerance test (OGTT). These findings suggest that periodontal disease is a risk factor for diabetes, although more evidence is needed.Methods: A total of 193 Japanese men aged 50 to 54 years with at least 10 teeth were examined as part of a comprehensive health examination before retirement from the Japan Self-Defense Force. Alveolar bone loss of the posterior teeth was measured on a panoramic x-ray film. An OGTT was administered and impaired glucose tolerance (IGT) and diabetes were defined. The relationships between the mean ratio of alveolar bone loss to root length and OGTT results were analyzed after adjusting for known risk factors for diabetes.Results: The proportion of subjects with IGT increased significantly in the subjects with higher tertiles of alveolar bone loss (P < 0.05). In the multivariate logistic regression analysis excluding diabetic subjects, the adjusted OR for IGT to normal glucose tolerance (NGT) increased in subjects with higher tertiles of alveolar bone loss (P for trend = 0.03). In the subjects with the highest tertile of alveolar bone loss, the adjusted OR for IGT to NGT was 4.27 (95% confidence interval [0): 1.41 to 12.9; P= 0.01).Conclusion: The degree of alveolar bone loss is significantly associated with IGT, suggesting that periodontitis with alveolar bone loss is associated with impaired glucose tolerance.