Long-Term Effect of Mediterranean-Style Diet and Calorie Restriction on Biomarkers of Longevity and Oxidative Stress in Overweight Men
Long-Term Effect of Mediterranean-Style Diet and Calorie Restriction on Biomarkers of Longevity and Oxidative Stress in Overweight Men
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DOI：
10.4061/2011/293916
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发表时间：
2011-01-01
影响因子：
2.1
通讯作者：
Giugliano, Dario
中科院分区：
文献类型：
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作者：
Esposito, Katherine;Di Palo, Carmen;Giugliano, Dario
我们报告了地中海式饮食（有或没有热量限制）对超重男性衰老和氧化应激生物标志物的影响。192名男性被随机分配到地中海式饮食或传统饮食。干预计划是基于在超重组（MED饮食组）中实施地中海饮食模式，与肥胖组（生活方式组）中的卡路里限制和增加体力活动相关。这两组都与两个匹配的对照组（建议组）的参与者进行了比较。2年后，组间体重减轻有显著差异，为-14公斤（95% CI -20至-8），生活方式组和-2.0 kg（-4.4至0），差异为-11.9 kg（CI -19至-4.7 kg，P < .001）;此外，2年时两组间胰岛素水平存在显著差异，（P = 0.04）、8-iso-PGF 2 α（P = 0.037）、葡萄糖（P = 0.04）和脂联素（P = 0.01）。超重或肥胖男性长期坚持地中海式饮食（有或无热量限制）与多种风险因素的显著改善相关，包括更好的心血管风险特征，降低氧化应激和改善胰岛素敏感性。
We report the effects of a Mediterranean-style diet, with or without calorie restriction, on biomarkers of aging and oxidative stress in overweight men. 192 men were randomly assigned to either a Mediterranean-style diet or a conventional diet. The intervention program was based on implementation of a Mediterranean dietary pattern in the overweight group (MED diet group), associated with calorie restriction and increased physical activity in the obese group (lifestyle group). Both groups were compared with participants in two matched control groups (advice groups). After 2 years, there was a significant difference in weight loss between groups, which was -14 kg (95% CI -20 to -8) in lifestyle groups and -2.0 kg (-4.4 to 0) in the advice groups, with a difference of -11.9 kg (CI -19 to -4.7 kg, P < .001); moreover, there was a significant difference between groups at 2 years for insulin (P = .04), 8-iso-PGF2 alpha (P = .037), glucose (P = .04), and adiponectin (P = .01). Prolonged adherence to a Mediterranean-style diet, with or without caloric restriction, in overweight or obese men is associated with significant amelioration of multiple risk factors, including a better cardiovascular risk profile, reduced oxidative stress, and improved insulin sensitivity.