Diminished cortisol responses to psychosocial stress associated with lifetime adverse events - A study among healthy young subjects
Diminished cortisol responses to psychosocial stress associated with lifetime adverse events - A study among healthy young subjects
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DOI：
10.1016/j.psyneuen.2007.11.004
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发表时间：
2008-02-01
影响因子：
3.7
通讯作者：
Spinhoven, Philip
中科院分区：
文献类型：
--
作者：
Elzinga, Bernet M.;Roelofs, Karin;Spinhoven, Philip
背景：动物和人类研究发现，先前的应激事件可导致HPA轴反应性的改变。本研究的目的是调查儿童期不良事件对年轻健康受试者（n = 80）的皮质醇对心理社会应激反应的作用。方法：在暴露于心理社会应激任务之前、期间和之后，测量了暴露于高（n = 33）和低（n = 47）儿童期不良事件的健康男性和女性的唾液皮质醇水平。与没有不良生活事件的个体相比，有不良生活事件史的个体的皮质醇反应明显迟钝，基线皮质醇水平没有差异。这一发现似乎主要是由男性推动的。组没有任何其他生理或主观的压力措施，包括心率，血压，和主观tension.Conclusions：这些研究结果表明，至少在健康的年轻队友，不良的童年事件与HPA轴功能的变化。需要进行纵向研究，以调查皮质醇反应迟钝是否是精神疾病病因学的一个危险因素，或者更确切地说，反映了心理病理学发展方面的弹性。(c)2007爱思唯尔有限公司保留所有权利。
Background: Animal and human studies have found that prior stressful events can result in an altered reactivity in the HPA axis. The aim of the present study was to investigate the role of adverse events in childhood on cortisol reactivity to psychosocial stress in young healthy subjects (n = 80).Methods: Salivary cortisol levels were measured before, during and after exposure to a psychosocial stress task in healthy men and women with high (n = 33) and tow (n = 47) exposure to adverse childhood events.Results: A significant blunted cortisol response was found in individuals with a history of adverse events compared to individuals with no adverse life events, with no differences in baseline cortisol levels. This finding appeared to be primarily driven by men. The groups did not differ on any other physiological or subjective stress measure, including heart rate, blood pressure, and subjective tension.Conclusions: These findings suggest that, at least in healthy young mates, adverse childhood events are associated with changes in HPA-axis functioning. Longitudinal studies are needed to investigate whether the blunted cortisol response is a risk factor in the etiology of psychiatric disorders or rather reflects resiliency with regard to the development of psychopathology. (c) 2007 Elsevier Ltd. All rights reserved.