Cerebrospinal fluid and serum levels of neuron-specific enolase in patients with schizophrenia
Cerebrospinal fluid and serum levels of neuron-specific enolase in patients with schizophrenia
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DOI：
10.1016/0165-1781(92)90133-n
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发表时间：
1992-08
影响因子：
11.3
通讯作者：
M. Egan;R. El-Mallakh;R. Suddath;J. Lohr;R. Wyatt
中科院分区：
文献类型：
--
作者：
M. Egan;R. El-Mallakh;R. Suddath;J. Lohr;R. Wyatt
一些精神分裂症患者似乎有脑部异常，包括第三脑室和侧脑室扩大，以及颞叶结构体积缩小。这些异常可以归因于发育异常或神经退化过程。神经元特异性烯醇化酶(NSE)是一种主要存在于神经元和神经内分泌细胞中的蛋白质，已被用作神经元损伤或变性的指标。本文比较了50例急慢性精神分裂症患者脑脊液和血清中NSE水平，并与正常对照组和神经对照组进行了比较。采用双抗体固相碘化放射免疫法测定血清NSE水平。没有证据表明精神分裂症患者的脑脊液中NSE水平升高，而患有神经系统疾病的对照组患者脑脊液中NSE水平升高。然而，由于NSE从脑脊液中迅速清除，升高的水平可能被忽略了。未用药的患者往往比用药的患者的水平低。
Some patients with schizophrenia appear to have brain abnormalities, including enlarged third and lateral ventricles and reduced volumes of temporal lobe structures. These abnormalities could be attributed to a developmental abnormality or a neurodegenerative process. neuron-specific enolase (NSE), a protein that is found primarily in neurons and neuroendocrine cells, has been used as an index of neuronal damage or degeneration. Levels of NSE in cerebrospinal fluid (CSF) and serum from 50 patients with acute and chronic schizophrenia were compared with those in normal and neurological control subjects. A double-antibody, solid phase iodinated radioimmunoassay was used to determine NSE levels. There was no evidence of elevated levels in patients with schizophrenia, whereas control subjects with neurological illnesses had increased levels of NSE in CSF. Because NSE is rapidly cleared from CSF, however, elevated levels could have been missed. Unmedicated patients tended to have lower levels than medicated patients.