Study of prostate delineation referenced against a gold standard created from the visible human data
Study of prostate delineation referenced against a gold standard created from the visible human data
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DOI：
10.1016/j.radonc.2007.08.001
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发表时间：
2007-11-01
影响因子：
5.7
通讯作者：
Gerig, Lee
中科院分区：
文献类型：
--
作者：
Gao, Zhanrong;Wilkin, David;Gerig, Lee
目的：为了测量间和观察者内的变化和系统误差在CT前列腺划定，其中个人划定参考金标准从摄影解剖图像从可视人体项目（VHP）。材料和方法：VHP男性的CT和解剖图像的形式为这项研究的基本数据集。金标准是基于1mm厚的解剖摄影图像建立的。这些与用于靶勾画的3 mm厚CT图像配准。共120个器官划定进行了6个放射肿瘤学家。结果：医生划定的前列腺体积平均30%以上的“真正的”前列腺体积，但平均只包括84%的金标准体积。我们的研究发现了一个系统的描绘错误，前列腺的后部总是错过了，而向前一些正常组织总是被定义为target.Conclusions：我们的数据表明，放射肿瘤学家更关心的是无意列入直肠组织比他们在丢失的前列腺体积。相比之下，它们可能会过度延伸前列腺的前边界，以包围膀胱等正常组织。(c)2007爱思唯尔爱尔兰有限公司保留所有权利。
Purpose: To measure inter- and intra-observer variation and systematic error in CT based prostate delineation, where individual delineations are referenced against a gold standard produced from photographic anatomical images from the Visible Human Project (VHP).Materials and methods: The CT and anatomical images of the VHP male form the basic data set for this study. The gold standard was established based on I mm thick anatomical photographic images. These were registered against the 3 mm thick CT images that were used for target delineation. A total of 120 organ delineations were performed by six radiation oncologists.Results: The physician delineated prostate volume was on average 30% larger than the "true" prostate volume, but on average included only 84% of the gold standard volume. Our study found a systematic delineation error such that posterior portions of the prostate were always missed while anteriorly some normal tissue was always defined as target.Conclusions: Our data suggest that radiation oncologists are more concerned with the unintentional inclusion of rectal tissue than they are in missing prostate volume. In contrast, they are likely to overextend the anterior boundary of the prostate to encompass normal tissue such as the bladder. (c) 2007 Elsevier Ireland Ltd. All rights reserved.